Skin Appendage Tmour

     

http://www.histopathology-india.net/SwCa.htm

 
                                  HISTOPATHOLOGY INDIA.COM

 Microcystic Adnexal Carcinoma

          Dr  Sampurna Roy  MD

 
February 2008

Case Index

Infectious Disease Online; INDEX: A-D ; INDEX: E-L ; INDEX: M-P INDEX: Q-Z ; FUNGAL DISEASE ; VIRAL DISEASE.

Benign sweat gland tumours

Cysts:

Hydrocystoma -Eccrine/Apocrine

Hamartomas:

Eccrine/Apocrine naevus

Eccrine Angiomatous Hamartoma

Porokeratotic eccrine ostial naevus

Benign Neoplasms:

Syringocystadenoma Papilliferum

Hidradenoma Papilliferum

Nipple Adenoma

Syringoma

Spiradenoma

Cylindroma

Chondroid Syringoma (benign mixed tumour)

Poroma

Hidradenoma

Apocrine adenoma

Papillary eccrine adenoma

Syringofibroadenoma

Malignant sweat gland tumour 

Low grade:

Microcystic adnexal carcinoma

Eccrine epithelioma

Adenoid cystic carcinoma

Mucinous carcinoma

Primary extramammary Paget’s disease

Intermediate grade:

Porocarcinoma

Digital papillary adenocarcinoma

High grade:

Hidradenocarcinoma

Apocrine adenocarcinoma

Eccrine ductal carcinoma

Spiradenocarcinoma

Malignant cylindroma

Sebaceous tumours

Fordyce's Spots

Steatocystoma

Nevus Sebaceous

Folliculosebaceous Cystic Hamartoma

Sebaceous Hyperplasia

Sebaceoma

Sebaceous Adenoma

Sebaceous Carcinoma

                      
This is a rare form of sweat gland carcinoma which has a striking resemblance to the adenoid cystic carcinoma of the salivary glands. 

Adenoid cystic carcinomas are regarded by some authors as apocrine in origin.

Site: 

Located on the scalp and on the chest. Rarely the tumour arises from the skin of the eyelid.

Adenoid Cystic Carcinoma of the External Ear ; Pulmonary Adenoid Cystic Carcinoma.

Microscopic features:

  Images:     

- Cords of basaloid cells arranged in a cribiform pattern.
- Focal tubular areas.
- Cystic spaces containing basophilic mucinous material.
- Perineural invasion is an important feature.

Immunohistochemistry:

Epithelial membrane antigen:  Positive
CEA : sometimes positive
Cytokeratin, vimentin and S100 protein :  focal positive staining

Differential diagnoses: 

1. Adenoid basal cell carcinoma: [Adenoid cystic carcinoma is characterized by:   Absence of retraction artefact , absence of contiguity with the epidermis or hair sheaths ,  lack of peripheral palisading of the nuclei, and occasional presence of central apoptotic or even necrotic cells. Pseudocysts stain positively to Alcian blue and periodic acid-Schiff ].

2. Primary cutaneous cribriform carcinoma: 

Primary cutaneous cribriform carcinoma: a rare apocrine tumour.J Cutan Pathol. 2005 Sep;32(8):577-80.

Unlike most of the sweat gland carcinomas, this tumour tends to recur locally and rarely spreads to lymph nodes or distant organs.

                        

 Abstracts:

Primary cutaneous adenoid cystic carcinoma metastatic to cervical lymph nodes.Head Neck. 2000 Jan;22(1):84-6

Primary cutaneous adenoid cystic carcinoma of the eyelid.Am J Ophthalmol. 2001 Feb;131(2):281-3.

Primary cutaneous adenoid cystic carcinoma with lymphnode metastasis. Am J  Dermatopathol 1998; 20: 571-577   

. A comparative immunohistochemical study of adenoid cystic carcinoma of the skin and salivary glands. Am J Dermatopathol 1991;13: 162-168

Primary adenoid cystic carcinoma masquerading as syringoma of the scalp. Am J Dermatopathol. 1990; 12: 169-174

Primary adenoid cystic carcinoma : case report,  immunohistochemistry, and review of the literature. Br J Dermatol 1988; 118: 567-578  

Primary cutaneous adenoid cystic carcinoma. J Am Acad Dermatol 1987; 17: 113-118 

Primary adenoid cystic carcinoma of the skin.  A clinical, histological and immunohistochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma. Am J Dermatopathol 1986; 8: 2-13

Primary cutaneous adenoid cystic carcinoma. Arch Dermatol 1984; 120: 774-777 

Adenoid cystic carcinoma involving the external auditory canal. A clinicopathologic study of 16 cases. Cancer 1982; 50: 2873-2883

Sweat-gland carcinomas: prognosis related to histological type. Histopathology 1980; 4: 445-466

 

 
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Tumours of the Hair Follicle

Hair Germ Differentiation:

Trichoepithelioma 

Desmoplastic Trichoepithelioma

Trichofolliculoma

Trichoblastoma

Cutaneous lymphadenoma

                          
    
Infundibular differentiation:

Trichoadenoma

Dilated Pore of Winer

Pilar Sheath Acanthoma

Tumour of Follicular Infundibulum

Outer root sheath differentiation:
                    
Trichilemmoma

Trichilemmal Carcinoma

Proliferating Trichilemmal Cyst (Pilar Tumour)

Matrical differentiation:
                  
Pilomatrixoma and Pilomatrix Carcinoma


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