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An
outline of the anatomy and normal histology of the stomach for
pathologists. Reporting of gastric biopsies (non-neoplastic gastric lesions). Pathology and pathogenesis of peptic ulcer. Helicobacter pylori associated Gastritis Reactive /Reflux/ Chemical Gastritis Other Non-Neoplastic Gastric Lesions Benign tumour and tumour- like lesions Gastrointestinal Stromal Tumour |
Normal histology of the small intestine for anatomic pathologists |
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-
Also
known as
Type A gastritis
is
limited to
corpus-fundus mucosa. - Patient usually presents with pernicious anaemia. - Diffuse atrophy of parietal and chief cell mass. - Hypo or achlorhydria , hypergastrinemia, decreased pepsinogen levels. - Associated with antibodies to parietal cells, intrinsic factor and gastrin receptor. - Cobalamin deficiency eventually leads to pernicious anaemia. - May develop gastric polyps. - Increased risk of developing gastric carcinoma. Gross appearance : Pathology located in the gastric corpus. Severe atrophy of the cell coats including muscle.Mucosa thinned out with pebbled appearance. Microscopic features: Early stage: Mononuclear cells consisting of lymphocytes and plasma cells in the lamina propria. Usually located around fundic glands and infiltration of the glands by lymphocytes. Glandular destruction is present. Focal mucous neck cell hyperplasia Florid stage: Parietal and chief cell atrophy. Increased lymphocytic infiltration. Focal intestinal metaplasia. End stage: Fundic mucosa is completely replaced by pyloric or intestinal glands. -Other features: In patients with pernicious anaemia the superficial gastric epithelium may appear megaloblastic. Focal pancreatic metaplasia is sometimes present. G-cell hyperplasia in the antrum Hypergastrinaemia leads to hyperplasia of corpus enterochromaffin cells (ECL cells), causing first linear, then nodular lesions and eventually multiple microcarcinoids and carcinoid tumours. In cases of co-existing helicobacter pylori infection, histological features of both Type A and Type B gastritis are present. Visit : Chronic gastritis ; Acute Gastritis |
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Abstracts:
Autoimmune gastritis. A clinicopathologic study of 25 cases.Cesk Patol. 2005 Oct;41(4):137-42.
Pancreatic acinar cell
metaplasia in autoimmune gastritis.
Atrophic body gastritis:
distinct features associated with Helicobacter pylori infection.
Helicobacter 1997 June; 2 (2): 57-64
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Enteropathy-associated T-cell lymphoma
Lesions causing
small bowel obstruction and bleeding - |
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Mycobacterium Tuberculosis Mycobacterium Avium Intracellulare Necrotizing Enteritis (pig-bel) Necrotizing "Malignant" External Otitis Norwalk Virus related Diarrhea Opportunisitc Infection: Role of cytopathology in the diagnosis |
| Pathogens commonly affecting Small Intestine |