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Surgical-Pathology.com
Environmental Pathology Online
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Normal histology of the small intestine for anatomic pathologists An approach to evaluation of small intestinal biopsy. |
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Also
known as
Type A gastritis
is
limited to
corpus-fundus mucosa. - Patient usually presents with pernicious anaemia. - Diffuse atrophy of parietal and chief cell mass. - Hypo or achlorhydria , hypergastrinemia, decreased pepsinogen levels. - Associated with antibodies to parietal cells, intrinsic factor and gastrin receptor. - Cobalamin deficiency eventually leads to pernicious anaemia. - May develop gastric polyps. - Increased risk of developing gastric carcinoma. Gross appearance : Pathology located in the gastric corpus. Severe atrophy of the cell coats including muscle.Mucosa thinned out with pebbled appearance. Microscopic features: Early stage: Mononuclear cells consisting of lymphocytes and plasma cells in the lamina propria. Usually located around fundic glands and infiltration of the glands by lymphocytes. Glandular destruction is present. Focal mucous neck cell hyperplasia Florid stage: Parietal and chief cell atrophy. Increased lymphocytic infiltration. Focal intestinal metaplasia. End stage: Fundic mucosa is completely replaced by pyloric or intestinal glands. -Other features: In patients with pernicious anaemia the superficial gastric epithelium may appear megaloblastic. Focal pancreatic metaplasia is sometimes present. G-cell hyperplasia in the antrum Hypergastrinaemia leads to hyperplasia of corpus enterochromaffin cells (ECL cells), causing first linear, then nodular lesions and eventually multiple microcarcinoids and carcinoid tumours. In cases of co-existing helicobacter pylori infection, histological features of both Type A and Type B gastritis are present. Visit : Chronic gastritis ; Acute Gastritis |
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Enteropathy-associated T-cell lymphoma
Lesions causing
small bowel obstruction and bleeding - |
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Mycobacterium Tuberculosis Mycobacterium Avium Intracellulare Necrotizing Enteritis (pig-bel) Necrotizing "Malignant" External Otitis Norwalk Virus related Diarrhea Opportunisitc Infection: Role of cytopathology in the diagnosis |
| Pathogens commonly affecting Small Intestine |