Histopathological features in acute gastritis:
Edema in lamina propria; Slight hyperemia in the interfoveolar area ;
Surface epithelium is intact ; Scattered neutrophils within mucosal
epithelial cells - this signifies active inflammation.
-With more severe mucosal damage, erosion and hemorrhage develops.
[Erosion is defined as loss of superficial epithelium causing a defect
in the mucosa that does not cross the muscularis mucosa.]
-Lesion is acccompanied by a dense acute inflammatory infiltrate and
extrusion of fibrin, containing purulent exudate into the lumen.
-Deep mucosa (glandular zone) is usually unaffected unless stress
ulcer results due to local necrosis.
-Crypts may be dilated & filled with acute inflammatory cells in
regeneration ; Elongation of pit ; Pseudostratified appearance of
superficial epithelium; Residual cluster of neurtrophils in the pit ;
Residual cluster of neutrophils in the pit.
Pathologists should be careful not to diagnose regenerative changes as
Regenerative changes include:
Regular glands arranged parallel to one another ;
separating the glands ;
Basally located nucleii ; Basophilic cytoplasm ;
Increased nuclear cytoplasmic
Summary of histological
-Massive mucosal necrosis
Rare types of acute
i) Generalized streptococcal infection
ii) Viral infection
Distended thickened wall. Dark red in colour.
Fibrinopurulent exudate on serosal surface.
Submucosa thickened and edematous.
Mucosa is haemorrhagic and partly sloughed.
Edema and acute inflammation in the submucosa with or without
Mucopurulent exudate may be present in the mucosa.
Deep muscle congestion and necrosis.
Intravascular thrombosis in mural vessels.
Caused by gas forming organisms.
Air filled cystic space together with other features noted in