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               Fibrous Hamartoma of Infancy

           Dr Sampurna Roy MD

 
 

May 2009

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Adenomatoid tumor is a relatively uncommon, benign neoplasm of mesothelial origin that is usually confined to the male and female genital tracts (located in the myometrium, fallopian tube, ovary, epididymis, tunica albuginea, and testicular parenchyma).

Rare extragenital adenomatoid tumors have been identified in the adrenal glands, heart, mesentery, pleura, and lymph nodes.

Macroscopic features:  Two types of gross features have been described:  Small, solid tumours and large, cystic ones.   Image Link

Microscopic features:  These tumours are composed of fibrous tissue, which are separated by numerous slit-like and pseudotubular spaces. The tumour may exhibit a variety of appearances (papillary, adenoid, tubular and solid patterns). In some cases marked cytoplasmic vacuolisation may produce  a signet ring cell appearance and mimic diffuse mesothelioma.

    Image Link1 Image Link2 Image Link3 ;  Image Link4 .

The mesothelial origin of the adenomatoid tumor can be easily documented by such ancillary tests as immunohistochemical or electron microscopic studies.

                 

ABSTRACTS:

Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases.Gac Med Mex. 2006 Jan-Feb;142(1):59-66.

Adenomatoid tumor of the adrenal gland: a clinicopathologic study of 3 cases.Ann Diagn Pathol. 2005 Feb;9(1):11-5.

Cystic adenomatoid tumor of the mediastinum.Am J Surg Pathol. 2004 Jan;28(1):132-8.

Adenomatoid tumors of the female and male genital tracts express WT1.Int J Gynecol Pathol. 2004 Apr;23(2):123-8.

Infarcted adenomatoid tumor: a report of five cases of a facet of a benign neoplasm that may cause diagnostic difficulty.Am J Surg Pathol. 2004 Jan;28(1):77-83.

Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors.Ann Diagn Pathol. 2003;7(5):273-7.

Extragenital adenomatoid tumor of a mediastinal lymph node.Mayo Clin Proc. 2003;78(3):350-4.

Adenomatoid tumor of the pancreas: a case report with comparison of histology and aspiration cytology.Mod Pathol. 2003;16(6):613-7

Adenomatoid tumor of the adrenal gland with micronodular adrenal cortical hyperplasia.Hum Pathol. 2003;34(8):818-21

Adenomatoid tumor of the adrenal gland: a clinicopathologic study of five cases and review of the literature.Am J Surg Pathol. 2003;27(7) :969-77.

Diffuse uterine adenomatoid tumor in an immunosuppressed renal transplant recipient.Int J Gynecol Pathol. 2003;22(2):198-201.

Chronic epididymitis (epididymal nodule) mimicking an adenomatoid tumor--case report with review of literature. Int Urol Nephrol. 2002;34(2):219-22

Adenomatoid tumors of the uterus: an analysis of 60 cases.Int J Gynecol Pathol. 2002;21(1):34-40.

Uterine adenomatoid tumors confirmed by immunohistochemical staining. Arch Gynecol Obstet. 2001 Aug;265(3):151-4.

Clinical pathological analysis of adenomatoid tumor in uterus and ovaries.Zhonghua Bing Li Xue Za Zhi. 2001;30(1):43-5.

Immunohistochemical evidence for mesothelial origin of paratesticular adenomatoid tumour. Histopathology. 2000 Feb;36(2):109-15

Uterine diffuse adenomatoid tumor. Does it represent a different biological entity? Gynecol Obstet Invest. 1998;46(1):68-72.

Adenomatoid tumor of the heart: report of a case.Am J Surg Pathol. 1997 Nov;21(11):1378-80.

Adenomatoid tumor of the male genital tract -- a pathological study of eight cases and review of the literature.Acta Pathol Jpn. 1980 Nov;30(6):883-906.

                 

 

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