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Pathology of Adenomatoid Tumour              

Dr Sampurna Roy MD





Adenomatoid tumour is a relatively uncommon, benign neoplasm of mesothelial origin that is usually confined to the male and female genital tracts (located in the myometrium, fallopian tube, ovary, epididymis, tunica albuginea, and testicular parenchyma).

Some cases with malignant behaviour have been reported in the genital tract.

Rare extragenital adenomatoid tumors have been identified in the adrenal glands, heart, mesentery, pleura, and lymph nodes.

Macroscopic features: 

Two types of gross features have been described:  1) Small, polypoid, pedunculated solid tumours and 2) large, cystic ones.  

Microscopic features: 


These tumours are composed of fibrous tissue, which are separated by numerous slit-like and pseudotubular spaces.

The tumour may exhibit a variety of appearances (papillary, adenoid, tubular and solid patterns).

In some cases marked cytoplasmic vacuolisation may produce a signet ring cell appearance and mimic diffuse mesothelioma.

Immunohistochemical examintion: The cells are Cytokeratin and Calretinin positive

The mesothelial origin of the adenomatoid tumor can be easily documented by such ancillary tests as immunohistochemical or electron microscopic studies.


Further reading:

Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases.

Adenomatoid tumor of the adrenal gland: a clinicopathologic study of 3 cases.

Cystic adenomatoid tumor of the mediastinum.

Adenomatoid tumors of the female and male genital tracts express WT1.

Infarcted adenomatoid tumor: a report of five cases of a facet of a benign neoplasm that may cause diagnostic difficulty.

Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors.

Extragenital adenomatoid tumor of a mediastinal lymph node.

Adenomatoid tumor of the pancreas: a case report with comparison of histology and aspiration cytology.

Adenomatoid tumor of the adrenal gland with micronodular adrenal cortical hyperplasia.

Adenomatoid tumor of the adrenal gland: a clinicopathologic study of five cases and review of the literature.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)



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