Usually lower esophagus. Commonly arise from Barrett's metaplastic
mucosa. (rarely from gastric heterotopic mucosa).
Usually in middle aged white male . Average age is 57 years.
Flat, ulcerating , infiltrative lesion.
Wide range of
glandular features are noted (resemble gastric adenocarcinoma).
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-Mucinous adenocarcinoma (mucin production)
The backround Barrett's type mucosa may demonstrate areas of high grade
The tumour usually penetrates through the muscle coat. Perineural
invasion is noted Lymphnode metastasis is present.
The tumour has a poor prognosis .
What is intramucosal carcinoma of the esophagus?
Intramucosal carcinoma is characterized by tumour cells penetrating
through the basement membrane and infiltrating into the lamina propria
as single cells or in clusters.
Sometimes it can be extremely difficult to distinguish between high
grade dysplasia and intramucosal carcinoma.
Surgical pathology of
adenocarcinoma arising in Barrett's esophagus. Analysis of 67 cases.Am
J Surg Pathol. 1995 Feb;19(2):183-91.
Adenocarcinoma in the distal
esophagus with and without Barrett esophagus. Differences in symptoms
and survival rates.Arch
Surg. 1996 Jul;131(7):708-13.
Superficial adenocarcinoma of
the oesophagus arising in Barrett's mucosa with dysplasia: a clinico-pathological
study of 12 patients.Histopathology.