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CLEAR CELL TUMOURS OF SKIN
Epidermal-derived:
Clear cell acanthoma ; Bowen's disease ;
Basal cell carcinoma
Adnexal tumours:
Paget's disease;
Clear cell syringoma ;Clear cell hidradenoma
;
Clear cell hidradenocarcinoma ; Clear cell
porocarcinoma
; clear cell myoepithelioma ;
Tricholemmoma ;
Tricholemmal
carcinoma ;
Sebaceous adenoma;
Sebaceous carcinoma.
Nevomelanocytic:
Balloon cell nevus;
Balloon cell melanoma ; Clear cell melanoma ; Clear
cell sarcoma.
Mesenchymal:
Clear cell dermatofibroma;
Clear cell atypical fibroxanthoma
; Clear cell
fibrous papule.
Salivary gland:
Acinic cell carcinoma; Hyalinizing clear cell carcinoma ; Clear cell
mucoepidermoid carcinoma.
Metastases:
Renal cell carcinoma
(Abstract); Breast carcinoma ; Hepatocellular carcinoma ;
Pulmonary adenocarcinoma and mesothelioma
CLEAR
CELL CARCINOMA OF SKIN
1. Clear cell (hydropic) basal cell
carcinoma and squamous cell carcinoma
Image
link (Dr
Weems)
2.
Clear cell variant of Atypical fibroxanthoma
3.
Clear cell porocarcinoma
4 Hidradenocarcinoma
5. Sebaceous
carcinoma
6. Trichilemmal
carcinoma
7. Metastatic
clear cell adenocarcinoma of viscera (Eg.renal cell carcinoma)
8. Clear
balloon cell malignant melanoma
Image
link
(Dr Weems)
In
malignant clear cell eccrine tumour, (D/D -trichilemmal carcinoma), there
is absence of peripheral palisading and presence of acinar or ductal
differentiation that can be demonstrated by immunohistochemical stains for
CEA.
In basal cell carcinoma and squamous cell carcinoma clear cells represent
degenerative changes and may form epithelial lobules.
In sebaceous carcinoma the sebaceous cells display foamy cells with
centrally located indented nuclei.
IMMUNOHISTOCHEMICAL
PANEL
Pan-keratin
Ber-EP4 AE13/AE14 EMA
CEA CD68 S100
Clear cell
+
+
-
- - -
-
basal
cell carcinoma
Clear cell
+
-
- +/-
-
-
-
squamous
cell
carcinoma
Clear cell -
-
- - -
+ -
variant of Atypical Fibroxanthoma (positive
for vimentin
& actins)
Pan-keratin
Ber-EP4 AE13/AE14 EMA
CEA CD68 S100
Clear cell +
+/- -
+ +/- - +/-
eccrine carcinoma
Sebaceous +
+/- -
+ -
- -
carcinoma
(with multivacuolar
cytoplasmic pattern)
Pan-keratin
Ber-EP4 AE13/AE14 EMA
CEA CD68 S100
Balloon cell - -
- - - - +
melanoma
Trichilemmal +
-
+
+/- -
- -
carcinoma
Metastatic + +/-
- + +/- -
+/-
clear cell adenocarcinoma
Ca 125 or PLAP may be
(+)
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