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Dr Sampurna Roy
MD
 Site created by Dr Sampurna Roy MD
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| Images of Chondroid
Syringoma:
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Benign sweat gland tumours Cysts: Hydrocystoma -Eccrine/Apocrine Porokeratotic eccrine ostial naevus Benign Neoplasms: Syringocystadenoma Papilliferum Chondroid Syringoma (benign mixed tumour) Low grade: Primary extramammary Paget’s disease Intermediate grade: Digital papillary adenocarcinoma High grade: |
| Sebaceous tumours |
| Chondroid syringoma
represents the cutaneous counterpart of mixed tumor ("pleomorphic
adenoma") of salivary glands, therefore it is also termed 'mixed tumour of
the skin'. The cutaneous lesion has different behaviour in that it rarely
recurs even if inadequately excised. It is generally accepted that there are both eccrine and apocrine variants of mixed tumour of skin.
Age: Usually occurs in middle aged and elderly patients. Tumour consists of epithelial component set in a chondroid, myxoid and fibrous stroma ; There are epithelial nests, islands, ducts and tubular structures ; Tubules or lumina may be- i) Large, multilayered, or complex structures ii) Small relatively round tubules or simple tubules. Focal areas of apocrine secretion may be present ; In rare cases there are intracytoplasmic lumina of eccrine type; Some cases show follicular and sebaceous differentiation (shadow cells, other elements of hair follicles and sebocytes) ; Other features include: Keratinous cyst formation ; Presence of eosinophilic globules (collagenous spherulosis); Islands of squamous epithelium ; Areas of ossification. Immunohistochemistry: Epithelial cells are CEA and cytokeratin positive; The outer layer of ductal cells (myoepithelial cells) are Vimentin and S100 positive. Hyaline cell-rich chondroid syringoma :- Histopathological features: Lobulated neoplasm composed of hyaline cells with plasmacytoid features showing ovoid nuclei, with occasional invaginations, finely granular chromatin, and discrete nucleoli; the cytoplasm is deeply eosinophilic with occasional dot-shaped paranuclear hyaline inclusions ; Hyaline cells might possess an aberrant myoepithelial differentiation; Immunohistochemistry: Hyaline cells are strongly and diffusely positive for S-100 protein, vimentin, pan and high molecular weight cytokeratins. Cells are focally positive for GFAP, neuron-specific enolase, and cytokeratin 14. Differential diagnosis: Malignant melanoma and extra-skeletal myxoid-chondrosarcoma. Atypical mixed tumours:- Borderline features of malignancy characterized by an infiltrative margin, satellite tumour nodules, and tumour necrosis . These tumours do not metastasize. Malignant chondroid syringoma:- A few cases have been reported; More common in women ; Occurs most often in trunk and extremities ; May metastasize to both the regional and distant lymph nodes, causing the death of the patient. In these cases, radiation therapy follows the surgical excision. Microscopic features: Lobulated appearance ; Composed of epithelial and mesenchyme-like component (myxomatous and cartilaginous areas) ; Epithelial component predominates at the periphery of the tumour; Mesenchymal component is at the center; Scattered mitoses ; Variable pleomorphism. Immunohistochemistry: Positive staining for cytokeratin, S-100 protein, neuron- specific enolase and glial fibrillary acidic protein. Visit: Salivary gland-type mixed tumours of the Lung ;Pleomorphic Adenoma of the External Ear . |
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Surgical-Pathology.com
Environmental Pathology Online
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Myxoid
Tumours of Soft Tissue Classification of Soft Tissue Tumour Gross examination of soft tissue specimen A practical approach to histopathological reporting of soft tissue tumours Grading of soft tissue tumours Fibroblastic/Myofibroblastic tumours |
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Melanocytic tumours
Mongolian Spots /Ota's naevus /Ito's naevus Pigmented melanocytic lesions causing diagnostic problems Prognostic parameters of melanoma Superficial spreading melanoma |
| Verruca vulgaris; |
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PULMONARY PATHOLOGY
Congenital Cystic Adenomatoid Malformation Acute Respiratory Distress Syndrome Pulmonary Alveolar Proteinosis Localized Fibrous Tumour of the Pleura Pulmonary Lymphoproliferative Disease
Post-Transplant Lymphoproliferative Disease
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