Coccidioidomycosis is caused by
the dimorphic fungus Coccidioides immitis.
The organism is thick-walled, mature, spherules containing endospores.
Spherules rupture liberating endospores into surrounding tissue.
chronic, necrotizing lesions that clinically & pathologically resembles
High risk groups are
African-Americans and Asians, pregnant women during the third trimester, and
Construction or agricultural
workers, and archeologists who are exposed to dust are also at risk.
the south-western United States, parts of Mexico and South America.
Soil in semiarid areas.
Mode of infection:
Inhalation of airborne arthroconidia (barrel shaped infectious units) from
The contaminated soil may be disturbed
following excavation or after a natural disaster like dust storm or
Arthroconidia mature to form endospore containing
A- 60% of air born infections are
B- 40% cases are symptomatic.
Lung: Primary pulmonary coccidioidmycosis are acute disease with influenza-like symptoms associated
with suppurative or granulomatous pneumonitis with abundant organisms.
Initially, there is a solitary area of consolidation, sometimes diffuse
pneumonic consolidation or multiple foci of consolidation is seen.
Cavitation is the most common
complication, which may communicate with bronchial tree.
Hilar lymph nodes may or may not be involved.
Disseminated lesions (0.5-1% of patients) by hematogemous route are seen in meninges,
skin, soft tissue, bones, adrenals,
Central nervous system is affected in
50% patients with disseminated lesion.
Coccidial meningitis is a chronic lesion with
Granulomatous and suppurative lesions are noted affecting basilar process
and sometimes brain parenchyma and spinal cord.
Hydrochephalus is a
Primary infection is very rare following
inoculation of organisms at sites of trauma.
In disseminated disease the skin lesions
takes the form of verrucous
plaques (nasolabial fold), granulomatous papules and nodules usually on the
Subcutaneous abscesses or pustular lesions
and sinus tracts are also
. Usually kenee, ankle and wrist joints are involved.
osteomyelitis. Long bones as well as bones of hands, feet, pelvis and skull
may be involved.
Other organs involved include:
gastrointestinal tract, genito-urinary tract, pericardium and peritoneum
Case Link (Dr Y Tsutsumi)
In tissue the
inflammatory reaction is both purulent and granulomatous.
incite a polymorphonuclear response.
As the endospores mature into
spherules, the acute reaction is replaced by lymphocytes, plasma cells,
epithelioid cells and giant cells.
Lungs: Caseative pulmonary granuloma
Epithelioid cells and
giants cells may be noted,
Organisms are present within the granuloma,
Mature spherule with endospores,
Hyphae may be present
in the pulmonary cavities,
Often associated with
of the lesions are healed by fibrosis & calcification.
Skin: Non caseating granuloma in the upper and mid-
Thick walled spherules within the granuloma,
lesions and subcutaneous abscesses demonstrate abundant neutrophil
Some lymphocytes, histiocytes and eosinophils are also
1. Skin test ;
2. Serodiagnosis ;
3. Immunoflourescence- confirmatory.