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Collagenous
gastritis is a rare histopathological disorder of unknown origin,
characterized by a subepithelial collagen deposit greater than 10 micron
thick, associated with an inflammatory infiltrate of the gastric mucosa.
Related to
lymphocytic colitis,
collagenous colitis,
lymphocytic gastritis
& celiac sprue and is probably part of the
same disease spectrum.
-The
patient usually complains of watery diarrhea.
-Endoscopic features include nodular pattern with erythema of the
gastric body.
[
Collagenous gastritis: a report
of six cases. Am
J Surg Pathol. 2001
Sep;25(9):1174-9.
" 1) collagenous
gastritis occurring in children and young adults presenting with severe
anemia, a nodular pattern on endoscopy, and a disease limited to the
gastric mucosa without evidence of colonic involvement, and 2)
collagenous gastritis associated with collagenous colitis occurring in
adult patients presenting with chronic watery diarrhea. These findings
highlight the fact that subepithelial collagen deposition may be a
generalized disease affecting the entire gastrointestinal tract.
" ]
Histological
features:
- Subepithelial thickening of basement membrane (greater
than 10 microns).
- Focal superficial epithelial degeneration
- Dense lymphoplasmacytic infiltrate in the lamina propria.
- In some cases numerous intraepithelial lymphocytes may be
present.
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