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Cutaneous lymphadenoma is a rare tumour with distinctive histologic features. This entity was originally described as lymphoepithelial tumour of the skin by Santa Cruz and Barr in 1987. It was renamed cutaneous lymphadenoma in 1991.Cutaneous lymphadenoma.Am J Surg Pathol. 1991 Feb;15(2):101-10.

Ackerman et al considered that cutaneous lymphadenoma is a variant of trichoblastoma ("adamantinoid trichoblastoma").

Clinical presentation:  A single, small, non-ulcerated, dome-shaped, flesh-colored,  well-circumscribed, slowly enlarging nodule. The lesion has usually been present for many months or years.

Age & sex: Usually between 21 and 75 years without a sex predominance.

Site:  Face and scalp regions or legs.

Microscopic features:

 Multiple rounded islands or nests of epithelial cells ; Tumour lobules consist of an outer rim of palisading basaloid cells surrounding a central zone of large cells with clear cytoplasm and large vesicular cells ; Dense infiltrate of small, mature lymphocytes within the islands ; Tumour lobules embedded in a loose-to-dense fibrous stroma ;   Few scattered lymphocytes in the stroma ; Focal follicular differentiation and sometimes sebaceous differentiation; Focal mucinosis, osteoma formation or prominent sweat gland duct component in some cases ; Central keratinization in some lobules.

Immunohistochemistry:    Clear epithelial cells in the lobules and the basaloid peripheral cells: Cytokeratin positive.   Lymphoid component reacted with common leukocyte antigen (CLA) and T-cell markers (UCHL-1, CD3).   Some CD30+ large clear cells may be present.  Many large epithelial cells in the lobules and some dendritic cells in the stroma : S-100 positive.

Differential diagnosis:

Clear cell syringoma ;  clear cell basal cell carcinoma ;   lymphoepithelioma-like carcinoma of skin.  Article

Cutaneous lymphadenoma does not tend to recur after surgical excision.

Image Link: 

Case Link: Article  

Cutaneous lymphoadenoma: a rare clinicopathological entity.J Exp Clin Cancer Res. 2005 Sep;24(3):497-9.

Cutaneous lymphadenoma.J Am Acad Dermatol. 2003 Dec;49(6):1115-6.

Cutaneous lymphadenoma.J Eur Acad Dermatol Venereol. 2001 Sep;15(5):481-3.

Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma.J Cutan Pathol. 1999 Mar;26(3):119-24.

Benign lymphoepithelial tumor of the skin ("cutaneous lymphadenoma").Dermatol Online J. 1999 May;5(1):5.

Cutaneous lymphadenoma: an adnexal neoplasm with intralobular activated lymphoid cells.Am J Dermatopathol. 1998 Feb;20(1):74-8.

A skin lymphoepithelial tumor (skin lymphadenoma). Acta Med Port. 1998 Jun;11(6):555-8.

Nodular trichoblastoma with adamantinoid features.Am J Dermatopathol. 1996 ;18(2):192-5.

Cutaneous lymphadenoma. A peculiar variant of nodular trichoblastoma.Am J Dermatopathol. 1996;18(2):186-91.

Cutaneous lymphadenoma. A basal cell carcinoma with unusual inflammatory reaction pattern?Am J Dermatopathol. 1993;15(4):353-7.

Cutaneous lymphadenoma: a case report and review of the literature.Br J Dermatol. 1993 ;128(3):339-41.

Cutaneous lymphadenoma with ductal differentiation.J Cutan Pathol. 1992;19(5):429-33.

Cutaneous lymphadenoma with focal mucinosis.J Cutan Pathol. 1992;19(2):142-4.

Cutaneous lymphadenoma: report of 2 cases.Dermatology. 1992;185(1):62-5.

Lymphoepithelial tumor of the skin (abstr.). J Cutan Pathol 1987; 14: 345.

 

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