Cysts:

Hydrocystoma -Eccrine/Apocrine

Hamartomas:

Eccrine/Apocrine naevus

Eccrine Angiomatous Hamartoma

Porokeratotic eccrine ostial naevus

Benign Neoplasms:

Syringocystadenoma Papilliferum

Hidradenoma Papilliferum

Nipple Adenoma

Syringoma

Spiradenoma

Cylindroma

Chondroid Syringoma (benign mixed tumour)

Poroma

Hidradenoma

Apocrine adenoma

Papillary eccrine adenoma

Syringofibroadenoma

Folliculitis

Impetigo

Furuncle(Boil)

Carbuncle

Toxic Shock Syndrome

Granuloma Annulare

Necrobiosis Lipoidica

Necrobiotic Xanthogranuloma   

Rheumatoid Nodule

Lupus Vulgaris

Cutaneous Sarcoidosis

Melkersson Rosenthal Syndrome

Annular Elastolytic Giant Cell Granuloma

Skin lesion in Crohn's Disease

Blastomycosis-like pyoderma

Foreign body granuloma

Rosacea

Interstitial Granulomatous Dermatitis

Interstitial Granulomatous Drug Reaction

Granulomatous T-cell lymphoma

Cylindroma is a benign tumour in which apocrine and trichoepitheliomatous differentiation has been noted indicating complex hair follicle (folliculo-sebaceous-apocrine) rather than eccrine differentiation.      Visit: Cylindroma of the External Ear

Clinical presentation:  Clinically, the tumour usually presents as a solitary, slow growing rubbery lesion.

The multiple form is autosomal dominantly inherited on cyld1 gene on chromosome 16. This form is also known as 'turban tumour' and may be associated with spiradenoma. Some of these lesions are painful. This condition is associated with trichoepitheliomas and milia.

Site:  Usually located on the scalp, head and neck or trunk.

Microscopic features: Image Link1 ; Image Link2 ; Image Link3.

Histologically cylindroma is a circumscribed, non-encapsulated , dermal tumour without attachment to the epidermis . The lesion is composed of numerous oval and polygonal nests arranged in an interlocking 'jigsaw-like' pattern. There are two cell types, the peripheral cells are small and basophilic and central cells are larger and pale stained. Small ductal lumina may be present. Thick PAS positive hyaline bands surround tumour islands. Hyaline droplets within nests.

Malignant Cylindroma:

Cylindromas occasionally undergo malignant transformation. Malignant cylindromas are characterised by islands of cells displaying marked nuclear pleomorphism. There is increase in mitosis and many abnormal forms are identified. The tumour shows invasion into the surrounding tissue and loss of the delicate hyaline sheath.

      Spiradenoma: click  ;  Spiradenocarcinoma: click

       Clinical image(NEJM):    Image Link
      Image Links(Dr Weems):  Image1 ; Image2

                     

Spiradenocylindrocarcinoma: a malignant hybrid tumor.J Cutan Pathol. 2005 Jul;32(6):453 BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare. We found 48 cases of malignant spiradenomas and 33 cases of malignant cylindromas reported in the English literature. Benign tumors demonstrating both spiradenomatous and cylindromatous features have been infrequently reported. Recent immunohistochemical studies of these two tumors have provided compelling evidence that these two tumors may merely represent a single tumor type with a spectrum of histological features. CASE REPORT: We describe two cases of a malignant variant of this rare hybrid tumor occurring in a 62-year-old male and a 72-year-old female. CONCLUSION: We propose the term 'spiradenocylindrocarcinoma' to describe malignant tumors with features of both a spiradenoma and a cylindroma. In conjunction with histological features of malignancy, p53 and Ki-67 immunohistochemical staining may provide helpful clues in determining the malignant potential of this tumor. Further studies are needed to clarify the biologic behavior of such lesions. Fine needle aspiration cytology of breast cylindroma in a woman with familial cylindromatosis: a case report. BACKGROUND: That sweat gland type tumors occur occasionally in the breast is not surprising, as the breast and cutaneous sweat glands are embryologically related. Cylindromas present most commonly as solitary and sporadic dermal nodules on the face and scalp. Cases of multiple cylindromas are dominantly inherited, and the neoplasms are referred to as "turban tumors" when multiple lesions cover the scalp. Primary cylindroma of the breast has been reported once in the past. To the best of our knowledge, the fine needle aspiration cytology of primary breast cylindroma and its occurrence in the setting of familial cylindromatosis have not previously been reported. CASE: A 59-year-old woman presented with an ill-defined left breast mass. She had a personal and family history of dermal cylindromas on the head and face. Fine needle aspiration cytology demonstrated small, uniform cells with oval nuclei and finely granular cytoplasm, with some cells arranged around conspicuous cylinders of dense, acellular material. Excisional biopsy was recommended to exclude adenoid cystic carcinoma. Tissue biopsy revealed a benign cylindroma arising in breast parenchyma. CONCLUSION: Fine needle aspiration cytology of cylindroma very closely mimics that of adenoid cystic carcinoma. Although extremely rare, primary breast cylindroma is another entity to be included in the cytologic differential diagnosis of bland, basaloid cells associated with globular, extracellular material, a finding most commonly associated with adenoid cystic carcinoma.

Abstracts:

Defective Laminin 5 Processing in Cylindroma Cells.American Journal of Pathology. 2002;160:459-468.

Linkage and LOH studies in 19 cylindromatosis families show no evidence of genetic heterogeneity and refine the CYLD locus on chromosome 16q12-q13.Hum Genet. 2000;106(1):58-65.

Spiradenocylindromas of the skin: Tumors with morphological features of spiradenoma and cylindroma in the same lesion: Report of 12 cases.Pathology International, Volume 49, Number 5, 1999, pp. 419-425

Spiradenoma and Dermal Cylindroma: Comparative Immunohistochemical Analysis and Histogenetic Considerations . American Journal of Dermatopathology . 1997;19(2):154-161.

Cutaneous Adnexal Carcinoma Arising within a Solitary Cylindroma-Spiradenoma. American Journal of Dermatopathology.1996; 18(1):77-82, 

Familial cutaneous cylindromas: investigations in five generations of a family.J Am Acad Dermatol. 1995;33(2 Pt 1):199-206

Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene.Nat Genet. 1995;11(4):441-3.

Dermal cylindroma An immunohistochemical study of thirteen cases. Am J Dermatopathol .1995 ;17: 260-265.

Cutaneous cylindroma with malignant transformation. Cancer 1993 ; 72: 1618-1623.

Cylindroma expresses immunohistochemical markers linking it to eccrine coil. J Cutan Pathol 1993 ; 20: 40-43.

Malignant dermal cylindroma in a patient with multiple dermal cylindromas, trichoepitheliomas, and bilateral dermal analogue tumors of the parotid gland.Am J Dermatopathol. 1989;11(4):353-9.

Dermal eccrine cylindroma.Ann Otol Rhinol Laryngol.1989 ;98 (12 Pt 1):991-2.

Metamorphosis of dermal cylindroma: possible relation to malignant transformation. Case report of cutaneous cylindroma with direct intracranial invasion.J Am Acad Dermatol. 1985;12(1 Pt 2):188-95