Custom Search

        

 

Soft Tissue Pathology 

Pathology of Desmoplastic Fibroblastoma (Collagenous Fibroma) 

 Dr Sampurna Roy MD             

 

                                                                                                                      

 

 

Desmoplastic Fibroblastoma is a distinctive benign fibrous soft tissue tumour that was first described by Evans in 1995.

Clinical presentation:  The lesion presents as a firm, well circumscribed, painless mass of long duration and are commonly located in the subcutaneous tissue or skeletal muscle in adults.

The tumours range in size from 1 to 20 cm. 

Site:  This entity has been reported in various locations, including the upper extremities, posterior neck, upper back, lower extremities, abdominal wall, and hip.

Gross:  Macroscopically, the lesion presents as an elongated, lobulated, or disc-shaped mass with a firm consistency and a homogeneous grayish-white colour.

Microscopic features:  

 ;

The tumour is relatively hypocellular.

There is proliferation of bland  spindle or stellate shaped cells embedded in a fibromyxoid to densely fibrotic collagenous stroma.  

The stroma may contain a large amount of mucin which is positive with alcian blue.

Mitotic figures are very rare or absent, tumour necrosis is not seen, and vascularity is low.

The tumour often focally infiltrate the surrounding skeletal muscle and adipose tissue.

Immunohistochemistry:  Diffusely positive for vimentin.

In some cases there may be focal staining for smooth muscle actin.

S-100 protein, EMA , CD34, desmin and keratin are usually negative.

Electron microscopy: Revealed features consistent with a fibroblastic or myofibroblastic lineage.

Differential diagnosis:   Fibromatosis-   Collagenous fibroma should be differentiated from fibromatosis, which has a high risk of local recurrence if simple local excision is done.

Fibromatosis is more cellular and shows short fascicular arrangements of tumour cells and greater infiltration at the periphery than collagenous fibroma.

Neurofibroma Nodular fasciitis ;  Fibroma of tendon sheath ; Solitary fibrous tumour Perineurioma low-grade fibromyxoid sarcoma.

The tumour does not recur after complete surgical excision.

 

 

 

Further reading:

Desmoplastic fibroblastoma. A report of seven cases.

Collagenous fibroma (desmoplastic fibroblastoma): a new case originating in the palate.

Collagenous fibroma (desmoplastic fibroblastoma).

Collagenous fibroma (desmoplastic fibroblastoma): a unique presentation as a goiter in an 88-year-old man.

Collagenous fibroma of the arm: a report of two cases.

The morphological characteristics of desmoplastic fibroblastoma.

Collagenous fibroma (desmoplastic fibroblastoma): a report of seven cases.

Desmoplastic fibroblastoma.

Desmoplastic fibroblastoma (collagenous fibroma).

Collagenous fibroma (desmoplastic fibroblastoma): genetic link with fibroma of tendon sheath?

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

Histopathology-India.net

 

Pathopedia-India.com

 

Surgical Pathology.com

 

Pathology-India.com

 

Dermpath-India

 

Infectious Disease Online

 

Pathology Quiz Online 

 

Paediatric Pathology Online

 

Pancreatic Pathology Online

 

Paraganglioma-Online

 

Endocrine Pathology Online

 

Eye Pathology Online

 

Ear Pathology Online

 

Cardiac Path Online

 

Pulmonary Pathology Online

 

Lung Tumour Online

 

Mesothelioma-Online

 

Nutritional Pathology Online

 

Environmental Pathology Online

 

Soft Tissue Tumour Online

 

GI Path Online-India

 

Gallbladder Pathology Online

 

E-book - History of Medicine  

 

Microscope - Seeing the Unseen

 

 roypath.in

 

 

Disclaimer

Privacy Policy  

Advertising Policy

Copyright 2017  histopathology-india.net