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Pathology of Dermatophytosis

Dr Sampurna Roy MD

 

                                                                                                                      

 

 

The most important superficial mycoses is dermatophytosis, a clinical entity caused by a group of related filamentous fungi - Dermatophytes, of the genera Epidermophyton, Microsporum and Trichophyton.

Diseases produced by the dermatophytes occur worldwide and are known as tineas, or ringworm.

The clinical appearances are variable and depend on a number of factor: 

(i) Species of fungus

(ii) Site of infection

(iii) Immunological status of the patient 

(iv) Use of topical steroid.

Atypical presentation following use of topical steroids have been called 'tinea incognito'.

Subtypes:

1) Tinea Capitis: ( tinea of the head , scalp, eye-brow, and eyelash).

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Kerion is a boggy violaceous inflammatory area of dermal suppuration and folliculitis.

Favus is a chronic infection of the scalp and rarely of the glaborous skin which is usually acquired in childhood.

2) Tinea Faciei : Rare variant presenting as a facial  erythema with scaling

3) Tinea corporis (of the body): The term 'radiation port dermatophytosis'- is used for cases of tinea corporis localized to irradiated skin.

4) Tinea cruris (of the groin): Occurs exclusively in males. Have been noted in patients with AIDS.

Diaper dermatitis is a variant which predominantly affects infants.

5) Tinea Pedis (of the foot):  Common in swimmers.

6) Onychomycosis: Fungal infection of the nail. The lesion presents as thickening, discoloration, and deformity of the nails. Fungal organisms are present in the deeper portions of the nail plate and in the hypertrophic nail bed. PAS- stain is used to demonstrate the fungal elements.

7) Majocchi's granuloma:  It is common in females and often occurs in immunocompromised patients. The lesion presents as nodular and plaque-like lesions of the lower leg.

Microscopic features are of granulomatous perifolliculitis. The nodular granulomatous lesions in the dermis contain individual dermatophyte hyphae.

Microscopic features: 

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Note the "sandwich sign" where the hyphae are sandwiched at the interface between normal and abnormal layers of cornified cells"

Dermatophyte infection may display a wide range of microscopic features.

Changes in stratum corneum include:

(i)   Presence of neutrophils;

(ii)  Compact orthokeratosis ;

(iii)  Presence of 'Sandwich Sign' - Characterized by hyphae  sandwiched in between an upper normal basket weave stratum corneum and lower layer of abnormal stratum corneum - (compact orthokeratotic or parakeratotic in type).

Epidermis may show:  Mild spongiosis ; Prominent spongiotic vescicles (palms and soles) ; Rarely subcorneal or intraepidermal pustules ; Chronic cases show variable acanthosis.

Dermis may show sparse perivascular mixed inflammatory infiltrate or a heavy dermal infiltrate with involvement of  hair follicle.

Perifollicular neutrophils or a mixed inflammatory infiltrate may be present.

Dermatophytes are identified in the tissue as branched, septate hyphae and spores.

They usually stain with hematoxylin and eosin but are best demonstrated with special stains for fungi.

Hyphae and arthroconidia invade the stratum corneum, hair follicle and hair shafts.

The pattern of hair invasion may be ectothrix, endothrix or endoectothrix.

Occasionally, rupture of a hair follicle and release of fungal elements into the dermis elicits acute suppurative inflammation that eventually becomes granulomatous. 

Aggregates of hyphae embedded in and surrounded by abundant Splendore - Hoeppli material in the dermis and subcutaneous tissue may be misinterpretated by some pathologists as grains and granules found in Mycetoma.

The aggregates actually consist of clustered dermatophyte hyphae (pseudogranules) each ensheathed by Splendore- Hoeppli material.

Note: The presence of hyphae in the very thin compactly orthokeratotic zone in the lowermost part of the stratum corneum of a section stained by hematoxylin and eosin is diagnostic of dermatophytosis.

Special stain for fungi:  

Gomori-Methenamine Silver (GMS) ;

Periodic Acid-Schiff (PAS) ;

Gridley fungus ; GMS with Hematoxylin and Eosin counterstain (GMS/H&E).

 

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Further reading:

Dermatophytoses in children: study of 137 cases.

The "sandwich sign" of dermatophytosis

Dermatophytosis and the immune response.

Dermatophytoses in monterrey, mexico.

Dermatophytosis: the management of fungal infections.

Prevalence of dermatophytosis in University of Nigeria Teaching Hospital, Enugu, Nigeria: any change in pattern?

A 7-year survey of dermatophytoses in Crete, Greece

Dermatophytoses in forestry workers and farmers.

Onychomycosis in children: a survey of 46 cases.

Utility of histopathologic analysis in the evaluation of onychomycosis.

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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