 Site created by Dr Sampurna Roy MD
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Path Quiz Case- 85
Diagnosis: Mildly dysplastic compound
melanocytic naevus.
Dr. Sampurna Roy MD
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Melanocytic tumours 1. Acquired Melanocytic Naevus
Ancient Naevus
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Myxoid
Tumours of Soft Tissue Classification of Soft Tissue Tumour Fibroblastic/Myofibroblastic tumours |
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Normal Histology
of Skin
Gross examination of the skin specimen Reporting of biopsies taken for Inflammatory Skin Diseases Lichenoid (Interface)Tissue Reaction Pattern Vesiculobullous Reaction Pattern |
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Dysplastic naevi are usually compound naevi with peripheral
lentiginous and junctional activity and random cytological atypia in the
epidermal component. Dysplastic (atypical) nevus syndrome includes familial (originally known as B-K mole syndrome) and sporadic occurrence of multiple dysplastic naevi in an individual. Gross appearance: [A: Asymmetry , B: Border Irregularity, C: Colour Variation, D: Diameter more than 4mm , E: Elevation.] Salient Histological
Features:
(Usually a low-power diagnosis) Lentiginous and
nested hyperplasia noted in dysplastic naevus is characterized by
proliferation of melanocytes singly and in groups along the basal layer.
'Junctional nest disarray ' refers to uneven distribution and pattern of
junctional component. The rete ridges of the epidermis show hyperplasia
and fusion of adjacent retes. The narrow elongated spindle shaped
melanocytes run horizontally between the rete- ridges forming part of a
bridge. Reactive mononuclear cells are often present ; melanophages are noted in the upper dermis; there may be irregular distribution of pigment. Radial growth phase
melanoma is the most important differential diagnosis: |
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Abstracts: Histologic similarities between lentigo maligna and dysplastic nevus: importance of clinicopathologic distinction.J Cutan Pathol. 2005 Jul;32(6):405-12. Cutaneous melanocytic lesions: selected problem areas.Am J Clin Pathol. 2005 Dec;124 Suppl:S52-83. Grading of atypia in nevi: correlation with melanoma risk.Mod Pathol. 2003 Aug;16(8):764-71. Atypical histologic features in melanocytic nevi. Am J Dermatopathol. 2000 Oct;22(5):391-6.
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| WHO
CRITERIA FOR DYSPLASIA : MAJOR CRITERIA: -Basal(lentiginous and'nesting) proliferation of melanocytes. -Melanocytic atypia, lentiginous/epithelioid cell type. MINOR CRITERIA: -Inflammation -Increased vascularity with endothelial hyperplasia -Concentric eosinophilic fibrosis / lamellar fibroplasia -Bridging of epidermal rete ridges by atypical melanocytes |
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Pigmented melanocytic lesions causing diagnostic
problems Prognostic parameters of melanoma Superficial spreading melanoma |
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Skin Adnexal (Appendage) Tumours Epidermal tumours:Cutaneous Squamous Cell Carcinoma (Image &abstracts) Cutaneous infection and infestations |