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Pathology of Eccrine Ductal Carcinoma and Squamoid Eccrine Ductal Carcinoma


Dr Sampurna Roy MD     





Eccrine Ductal Carcinoma:

Eccrine ductal carcinoma is an exceedingly rare malignant sweat gland neoplasm composed of multiple ductal structures lined by pleomorphic cuboidal cells. 


The tumour has an infiltrative pattern.

Focal solid and cribriform areas are also present.

Mitotic activity is prominent.

There is usually no evidence of decapitation secretion.


Differential diagnosis:  Primary and metastatic ductal carcinoma of breast and salivary gland.

Squamoid Eccrine Ductal Carcinoma:

Cutaneous adnexal tumour showing features of eccrine ductal differentiation that are characterized by a prominent squamoid component.

The tumours usually presents as solitary dermal nodules on the head and neck areas and the extremities in elderly patients.

Microscopic features:  The tumour is characterized by a prominent squamous proliferation with atypia, keratinous cyst formation and squamous eddies which seem to merge with areas showing eccrine ductal differentiation, including ductular formations in continuity with eccrine ductal epithelium.

Further reading:

"Squamoid eccrine ductal carcinoma": an unusual low-grade case with follicular differentiation. Are these tumors squamoid variants of microcystic adnexal carcinoma?

Mohs micrographic surgery in the setting of squamoid eccrine ductal carcinoma: addressing a diagnostic and therapeutic challenge.

Squamoid eccrine ductal carcinoma: a case report and review of the literature.

Ductal eccrine carcinoma with squamous differentiation: apropos a case.

Eccrine ductal and acrosyringeal differentiation of the breast epithelium--a lesion associated with some metaplastic breast carcinomas.

Mohs micrographic surgery for squamoid eccrine ductal carcinoma.

Ductal eccrine carcinoma presenting as a Paget's disease-like lesion of the breast. Carcinomas of sweat glands: report of 60 cases.

Homologous carcinomas of the breasts, skin, and salivary glands. A histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma.

Squamoid eccrine ductal carcinoma.

Histologic spectrum of carcinomas with eccrine ductal differentiation (sweat-gland ductal carcinomas).





Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)









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