Eccrine ductal carcinoma

http://www.histopathology-india.net/SwCa.htm

Dr Sampurna Roy MD

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February 2009

Benign sweat gland tumours

Cysts:

Hydrocystoma -Eccrine/Apocrine

Hamartomas:

Eccrine/Apocrine naevus

Eccrine Angiomatous Hamartoma

Porokeratotic eccrine ostial naevus

Benign Neoplasms:

Syringocystadenoma Papilliferum

Hidradenoma Papilliferum

Chondroid Syringoma (benign mixed tumour)

Poroma

Hidradenoma

Apocrine adenoma

Papillary eccrine adenoma

Syringofibroadenoma

Malignant sweat gland tumour

Low grade:

Microcystic adnexal carcinoma

Eccrine epithelioma

Adenoid cystic carcinoma

Mucinous carcinoma

Primary extramammary Paget’s disease

Intermediate grade:

Porocarcinoma

Digital papillary adenocarcinoma

High grade:

Hidradenocarcinoma

Apocrine adenocarcinoma

Eccrine ductal carcinoma

Spiradenocarcinoma

Malignant cylindroma

Tumours of the Hair Follicle

Hair Germ Differentiation:

Trichoepithelioma

Desmoplastic Trichoepithelioma

Trichofolliculoma

Trichoblastoma

Cutaneous lymphadenoma

Infundibular differentiation:

Trichoadenoma

Dilated Pore of Winer

Pilar Sheath Acanthoma

Tumour of Follicular Infundibulum

Outer root sheath differentiation:

Trichilemmoma

Trichilemmal Carcinoma

Proliferating Trichilemmal Cyst (Pilar Tumour)

Matrical differentiation:

Pilomatrixoma and Pilomatrix Carcinoma

Eccrine ductal carcinoma is an exceedingly rare malignant sweat gland neoplasm composed of multiple ductal structures lined by pleomorphic cuboidal cells.

The tumour has an infiltrative pattern.

Focal solid and cribriform areas are also present.

Mitotic activity is prominent.

There is usually no evidence of decapitation secretion.

Images:

Differential diagnosis: Primary and metastatic ductal carcinoma of breast and salivary gland.

Abstracts:

Ductal eccrine carcinoma presenting as a Paget's disease-like lesion of the breast.Breast J. 2001 Sep-Oct;7(5):358-62.

Carcinomas of sweat glands: report of 60 cases.Arch Pathol Lab Med. 2001 Apr;125(4):498-505.

Homologous carcinomas of the breasts, skin, and salivary glands. A histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma.Am J Clin Pathol. 1998 Jan;109(1):75-84.

Squamoid eccrine ductal carcinoma.Histopathology. 1997 Mar;30(3):288-93.

Histologic spectrum of carcinomas with eccrine ductal differentiation (sweat-gland ductal carcinomas).Am J Dermatopathol. 1993 Oct;15(5):435-40.

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