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Soft Tissue Pathology

Pathology of Elastofibroma

Dr Sampurna Roy MD              

                                                                                                                      

 

 

Elastofibroma is a benign slowly progressive reactive lesion involving abnormal elastogenesis.

It was first reported by Jarvi and Saxen in 1959 and published in 1961.Jarvi O, Saxen E. Elastofibroma dorse. Acta Pathol Microbiol Scand Suppl. 1961;51:834.  

The lesion usually occurs in elderly patients and is relatively more common in females. Most cases are unilateral.

Bilateral involvement is present in about 10% of all cases.

The patient usually gives long history of manual labour.

Elastofibroma is usually located in the lower subscapular area and is probably caused by friction between the inferior edge of the scapula and the underlying chest wall.

Cases have also been reported in the deltoid muscle, hip, thigh and stomach.

Histologically, the lesion is characterized by an admixture of collagenous fibrous bands and elastic fibres.

Elastic stains (like Verhoeff-Van Gieson) reveal branched or unbranched fibres with irregular serrated margins or fibres arranged in globoid aggregates. 

Electron microscopic studies revealed that the fibres consisted of granular aggregations of electron dense material along a central core surrounded by an amorphous matrix containing microfibrils.

The collagen deposited in this disease is a mixture of Type I, II and III.

According to some authors it has been assumed there is an underlying genetic disposition or inherent enzymatic defect.

This benign reactive lesion has no tendency to recur and is usually treated by surgical excision.

 

Further reading: (Full text articles with images)

Elastofibroma Dorsi: A Histochemical and Immunohistochemical Study

Painful Elastofibroma Dorsi: A Report of a Case and a Brief Review of the Literature

Bilateral elastofibroma dorsi: a case report of an uncommon and under-diagnosed tumor

Elastofibroma dorsi management and outcomes: review of 16 cases

Bilateral elastofibroma dorsi: A case report

Elastofibroma Dorsi: Clinicopathological Analysis of 76 Cases

Elastofibroma Dorsi: An Uncommon Benign Pseudotumour

Elastofibroma dorsi differential diagnosis in chest wall tumours

Elastofibroma dorsi: A soft tissue masquerade

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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