Gastrointestinal Stromal Tumour

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 SMALL INTESTINE

 LARGE INTESTINE

          HISTOPATHOLOGY INDIA.COM

        Atypical Fibroxanthoma

         Dr Sampurna Roy MD

 
December  2009
Histopathology-India.net

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NORMAL HISTOLOGY OF ESOPHAGUS

AN APPROACH TO THE  REPORTING  OF ESOPHAGEAL BIOPSIES

BARRETT'S   ESOPHAGUS   (INTESTINAL METAPLASIA  DYSPLASIA  &   ADENOCARCINOMA)

BENIGN TUMOURS AND  TUMOUR - LIKE CONDITIONS  OF  ESOPHAGUS

 1. SQUAMOUS PAPILLOMA OF THE ESOPHAGUS

 2. INFLAMMATORY FIBROID POLYP OF THE ESOPHAGUS

 3. LEIOMYOMA OF THE ESOPHAGUS

 4. GRANULAR CELL TUMOUR OF THE ESOPHAGUS

 5. ESOPHAGEAL CYSTS

 6. GLYCOGENIC ACANTHOSIS

 7.FIBROVASCULAR POLYPS

REPORTING  OF  ESOPHAGEAL  RESECTION SPECIMENS

SQUAMOUS  EPITHELIAL  DYSPLASIA INCLUDING SQUAMOUS CELL CARCINOMA IN-SITU OF THE ESOPHAGUS

SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS

CARCINOSARCOMA OF THE ESOPHAGUS

SMALL CELL CARCINOMA OF THE ESOPHAGUS

               

Features of normal esophageal biopsy :(Visit-Blog)     

- Lining epithelium is stratified squamous non-keratinizing epithelium

- Basal layer ( polygonal or cuboidal cells) is one to four cell thick and account for 15% of its thickness. It is thickest at distal 2 - 3 cm of  squamous mucosa adjacent to Z-line.    

- Z -line is the squamocolumnar  junction which is histologically irregular. The glandular epithelium lying higher than   squamous mucosa. The lower esophageal sphincter is located in this area.

 

Immunohistochemical markers for Barrett's esophagus and associations to esophageal Z-line appearance.Scand J Gastroenterol. 2001 Sep;36(9):910-5.

- Melanocytes and neuroendocrine cells may be found in the basal layer.

- The lamina propria consists of loose connective tissue. Mucous glands (esophageal cardiac glands) are present in the distal part of the esophagus.

- Vascular connective tissue papillae can indent  the lamina propria as far as 2/3rd into mucosal thickness.

- Muscular mucosae is thicker in the esophagus than in any other part of the gut.

- At the esophagogastric junction gastric type glands are branched and divided into groups by smooth muscle fibres. Most of the cells are mucus secreting . Glands near the esophagogastric junction also contain parietal cells,  chief cells and endocrine cells.

- Submucosal mucous glands are present throughout its length.

               

External Image Links:  kmu.edu.tw 

   WebPath

                  

 

Normal esophageal mucosa

Gastro-esophageal junction

DRUG  RELATED  LESIONS  OF  THE GASTROINTESTINAL TRACT

Pathogens commonly affecting Small Intestine

Ascariasis

Cryptosporidium

Cytomegalovirus infection

Giardiasis

Hookworm Infection

Isosporiasis

Microsporidia

Mycobacterium Avium Intracellulare

Schistosomiasis

Whipple's disease

  Gastric Pathology

  Dr  Sampurna Roy MD

      

http://www.histopathology-india.net/GastricPathology.htm


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