www.histopathology-india.net/GIPath.htm

Granular cell tumor is a relatively rare, mostly benign lesion, that can be found in almost every organ, however, only 2% of the cases is esophageal. Malignant case has also been reported.

Clinical presentation: Esophageal GCTs are usually asymptomatic, small, and found incidentally on endoscopy done for other reasons. In some cases the patient complains of heartburn and dysphagia.

Site: Lower third of the esophagus.

Gross: Single or multiple pale yellow submucosal nodule.

Microscopic features are similar  to those found in other sites. Histopathologic reveals nests of polygonal cells with small hyperchromatic nuclei and abundant granular cytoplasm located in the lamina propria of the mucosa. Infiltrative granular cell tumours of the esophagus can invade the muscularis propria and the adventitia as well as the periesophageal organs. The diagnosis of malignant granular cell tumours of the esophagus can be established by demonstrating metastases.

Visit: Granular Cell Tumour of Bronchus

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Abstracts:

Malignant granular cell tumor of the esophagus.Virchows Arch. 2004 ;444(3):304-6.

Coexistence of esophageal granular cell tumor and squamous cell carcinoma: a case report.Dis Esophagus. 2002;15(1):88-92.

Multiple synchronous granular cell tumours of the esophagus: a case report.Ann Univ Mariae Curie Sklodowska [Med]. 2001;56:253-6.

Granular cell tumor of the esophagus.Orv Hetil. 2001 Apr 8;142(14):733-5.

Granular cell tumour of the oesophagus: a rare cause of dysphagia with differential diagnosis of oesophageal neoplastic lesions. Dig Liver Dis. 2000 Dec;32(9):803-6.

Granular-cell tumor of the esophagus: report of a case with a cytologic diagnosis based on esophageal brushing.Diagn Cytopathol. 1998 Dec;19(6):455-7.

Granular cell tumors of the esophagus: a clinical and pathologic study of 13 cases.Ann Thorac Surg. 1996 Sep;62(3):860-5.

Granular cell tumor of the esophagus: natural history, diagnosis, and therapy.Dig Dis Sci. 1988 Oct;33(10):1329-33.

AN APPROACH TO THE  REPORTING  OF ESOPHAGEAL BIOPSIES

BARRETT'S   ESOPHAGUS   (INTESTINAL METAPLASIA  DYSPLASIA  &   ADENOCARCINOMA)

BENIGN TUMOURS AND  TUMOUR - LIKE CONDITIONS  OF  ESOPHAGUS

 1. SQUAMOUS PAPILLOMA OF THE ESOPHAGUS

 2. INFLAMMATORY FIBROID POLYP OF THE ESOPHAGUS

 3. LEIOMYOMA OF THE ESOPHAGUS

 4. GRANULAR CELL TUMOUR OF THE ESOPHAGUS

 5. ESOPHAGEAL CYSTS

 6. GLYCOGENIC ACANTHOSIS

 7.FIBROVASCULAR POLYPS

REPORTING  OF  ESOPHAGEAL  RESECTION SPECIMENS

SQUAMOUS  EPITHELIAL  DYSPLASIA INCLUDING SQUAMOUS CELL CARCINOMA IN-SITU OF THE ESOPHAGUS

SMALL CELL CARCINOMA OF THE ESOPHAGUS

DRUG  RELATED  LESIONS  OF  THE GASTROINTESTINAL TRACT

http://www.histopathology-india.net/GCT.htm