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Pathology of Granular Cell

Tumour of the Esophagus

Dr Sampurna Roy MD


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Granular cell tumor is a relatively rare, mostly benign lesion, that can be found in almost every organ, however, only 2% of the cases is esophageal.

Malignant case has also been reported.

Clinical presentation: Esophageal granular cell tumors are usually asymptomatic, small, and found incidentally on endoscopy done for other reasons.

In some cases the patient complains of heartburn and dysphagia.

Site: Lower third of the esophagus.

Gross: Single or multiple pale yellow submucosal nodule.

Microscopic features are similar to those found in other sites.

Histopathologic reveals nests of polygonal cells with small hyperchromatic nuclei and abundant granular cytoplasm located in the lamina propria of the mucosa.

Infiltrative granular cell tumours of the esophagus can invade the muscularis propria and the adventitia as well as the periesophageal organs.

The diagnosis of malignant granular cell tumours of the esophagus can be established by demonstrating metastases.

Visit: Granular Cell Tumour of Bronchus

Further reading:

Malignant granular cell tumor of the esophagus.

Coexistence of esophageal granular cell tumor and squamous cell carcinoma: a case report.

Multiple synchronous granular cell tumours of the esophagus: a case report.

Granular cell tumor of the esophagus.

Granular cell tumour of the oesophagus: a rare cause of dysphagia with differential diagnosis of oesophageal neoplastic lesions. 

Granular-cell tumor of the esophagus: report of a case with a cytologic diagnosis based on esophageal brushing.

Granular cell tumors of the esophagus: a clinical and pathologic study of 13 cases

Granular cell tumor of the esophagus: natural history, diagnosis, and therapy.



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"Peaceful procession with banners of Granular Cell Tumour- "Spread Love, not Hate"


Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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