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Surgical-Pathology.com
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Granular cell tumor is a relatively rare, mostly benign lesion, that can be found in almost every organ, however, only 2% of the cases is esophageal. Malignant case has also been reported. Clinical presentation: Esophageal GCTs are usually asymptomatic, small, and found incidentally on endoscopy done for other reasons. In some cases the patient complains of heartburn and dysphagia. Site: Lower third of the esophagus. Gross: Single or multiple pale yellow submucosal nodule. Microscopic features are similar to those found in other sites. Histopathologic reveals nests of polygonal cells with small hyperchromatic nuclei and abundant granular cytoplasm located in the lamina propria of the mucosa. Infiltrative granular cell tumours of the esophagus can invade the muscularis propria and the adventitia as well as the periesophageal organs. The diagnosis of malignant granular cell tumours of the esophagus can be established by demonstrating metastases. |
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Abstracts: Malignant granular cell tumor of the esophagus.Virchows Arch. 2004 ;444(3):304-6. Granular cell tumor of the esophagus.Orv Hetil. 2001 Apr 8;142(14):733-5.
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