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Pathology of Giant Cell Tumour of Temporal Bone

Dr Sampurna Roy MD

 

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Giant cell tumours of the bone are rare, benign but locally aggressive lesions that primarily affect the epiphyses of long bones.

These tumours can occur in the skull, principally in the sphenoid and temporal bones.

Symptoms of these tumours depend on their site of origin but typically include headache, pain, visual field defects, and conductive hearing loss.

These tumours typically present in the third to fourth decades of life and rarely occur in patients under 20 years of age.

Radiographically, the tumours appear osteolytic and radiolucent without a sclerotic border.

Histologically, these tumours consist of three cell types: osteoclast-like multinucleated giant cells; round mononuclear cells resembling monocytes ; and spindle-shaped, fibroblast-like stromal cells.

Complete surgical resection is believed to be the most suitable treatment for giant cell tumour of temporal bone and postoperative radiotherapy may be effective.    

Visit: Osteosarcoma of Temporal Bone

 

Further reading

Giant Cell Tumor of the Skull: Review of the Literature.

A locally invasive giant cell tumor of the skull base: case report.

Giant cell tumor of the temporal bone with direct invasion into the middle ear and skull base: a case report.

Giant cell tumor of the skull in pediatric patients. Report of two cases.

Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear.

Giant cell tumor of the temporal bone-a case report.

Giant cell tumour of bone in the cavum tympani and petrous bone.

Giant cell tumor of temporal bone: a report of 7 cases.

True giant-cell tumour of the mastoid. A case report.

A case of osseous giant cell tumor of the temporal bone and tympanum.

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Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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