Custom Search



Vascular Tumours

Pathology of Glomeruloid Hemangioma

Dr Sampurna Roy MD              


Dermatopathology Quiz Case 33

Diagnosis: Glomeruloid Hemangioma 






Glomeruloid hemangioma is a term that was coined J.K.C. Chan and colleagues in 1990 because the condition is histopathologically similar to renal glomeruli.

This vascular tumour is associated with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes). POEMS syndrome: definitions and long-term outcome .Blood, 1 April 2003, Vol. 101, No. 7, pp. 2496-2506

Glomeruloid hemangiomas are more common among Japanese and clinically presents as multiple red or purple papules.

Microscopic features:

Microscopic Images of Glomeruloid Hemangioma


Microscopically, a typical case of glomeruloid hemangioma is characterized by dilated vascular spaces (sinusoidal) in the superficial dermis containing aggregates of capillaries, resembling renal glomeruli. 

Around the capillaries there are large cells which stain positively with endothelial markers.

Some PAS positive hyaline globules may be present.

These globules stain positively for immunoglobulins.


                                                                       CD31       CD34        UAE- 1       CD68
Capillary type endothelium:       
     +             +          +           -
             Sinusoidal endothelium:              
    +              -          -            +



Further reading:

Glomeruloid haemangioma with cerebriform morphology in a patient with POEMS syndrome.

Glomeruloid hemangioma leading to a diagnosis of POEMS syndrome.

Renal involvement in multicentric Castleman disease with glomeruloid hemangioma of skin and plasmacytoma.

Solitary glomeruloid haemangioma without POEMS syndrome.

Glomeruloid haemangioma and POEMS syndrome.

Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells.

A case of glomeruloid hemangioma associated with multicentric Castleman's disease.

Glomeruloid hemangioma. A cutaneous marker of POEMS syndrome.

Glomeruloid hemangioma. A distinctive cutaneous lesion of multicentric Castleman's disease associated with POEMS syndrome.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






Infectious Disease Online


Pathology Quiz Online 


Paediatric Pathology Online


Pancreatic Pathology Online




Endocrine Pathology Online


Eye Pathology Online


Ear Pathology Online


Cardiac Path Online


Pulmonary Pathology Online


Lung Tumour Online




Nutritional Pathology Online


Environmental Pathology Online


Soft Tissue Tumour Online


GI Path Online-India


Gallbladder Pathology Online


E-book - History of Medicine  


Microscope - Seeing the Unseen





Privacy Policy  

Advertising Policy

Copyright 2017