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Glomeruloid
hemangioma is a term that was coined J.K.C. Chan and colleagues in 1990
because the condition is histopathologically similar to renal glomeruli.
This vascular tumour is
associated with POEMS syndrome (polyneuropathy, organomegaly,
endocrinopathy, M-protein and skin changes).POEMS
syndrome: definitions and long-term outcome .Blood,
1 April 2003, Vol. 101, No. 7, pp. 2496-2506
Glomeruloid hemangiomas are
more common among Japanese and clinically
presents as multiple red or purple papules.
Microscopic features:
Microscopically a typical
case of glomeruloid hemangioma is characterized by dilated vascular spaces
(sinusoidal) in the superficial dermis containing aggregates of
capillaries, resembling renal glomeruli.
Around the capillaries there are
large cells which stain positively with endothelial markers. Some PAS
positive hyaline globules may be present. These globules stain positively
for immunoglobulins.
Immunohistochemistry:
CD31 CD34 UAE- 1 CD68
Capillary type endothelium:
+
+
+
-
Sinusoidal endothelium:
+
-
-
+
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