| 1.
Menetrier's disease
(hyperplastic or hypertrophic gastropathy, giant rugal hypertrophy):
Characterized
by hypertrophic rugae (1-3 cm in height).
Site:
Proximal greater curvature of the stomach or generalized in the body
and fundus.
Histological features: Foveolar hyperplasia, glandular atrophy. Elongated,
tortuous, dilated gastric pits are lined by mucous secreting cells.
Pits extend to the mucosa where they became cystic. Some cystically
dilated glands extend into the submucosa, producing gastritis cystica
profunda. Lamina propria edematous, infiltrated by smooth muscle
fibers.
Abstracts:
- The natural history of hypertrophic
gastropathy (Menetrier's disease). Report of a case with 16 year
follow up and review of 120 cases from the literature. Am J Med 1977;
63: 644-652
-
Hyperplastic gastropathy. Clinicopathologic
correlation. Am J Surg Pathol. 1991;15: 577-585
- Menetrier's disease: a form of hypertrophic
gastropathy or gastritis? Gastroenterology. 1993: 1310-1319 |