significance of gastric xanthoma:
This lesion may be confused with a
Associated with pathological lesions such as chronic gastritis &
intestinal metaplasia, atrophic gastritis,
and gastric ulcer .
islands are more common in certain conditions, such as diabetes
mellitus, cholesterolosis of the gallbladder, obesity, and
Dermatopathology Case 30
Age & sex :
More frequent in women and its incidence increases with age.
located at the antral and the lesser curvature, but occasionally present
in the body or fundus.
These lesions are rare in other parts of the gastrointestinal tract.
Cases have been reported in the small intestine, esophagus, and
Single or multiple, round to oval shaped well circumscribed, pale yellow
nodule or plaque (1 - 2 mm in diameter).
Microscopic features :
Collection of mature
lipid laden macrophages within the lamina propria.
carcinoma : Isolated tumour cells may be present in the lamina propria .
The tumour is positive for mucicarmine and cytokeratin. Gastric xanthoma:
Positive with Sudan black, oil red O (on frozen section), and CD68, and
are negative for PAS/alcian blue, mucicarmine and cytokeratin.
Clear cell carcinoid tumour of stomach
: Chromogranin A positive.
Packaged appearance of the cells and vascular stroma in xanthoma may
mimick neuroendocrine tumour.
disease and Mycobacterium auium-intracellulare are rare infections of
the stomach. Special stains (periodic acid Schiff with diastase and
acid-fast bacilli) helps in establishing the diagnosis.