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Path Quiz Case-89 : Diagnosis-
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An
outline of the anatomy and normal histology of the stomach for
pathologists. Reporting of gastric biopsies (non-neoplastic gastric lesions). Pathology and pathogenesis of peptic ulcer. Helicobacter pylori associated(TypeB) Gastritis Reactive /Reflux/ Chemical Gastritis (Type C) Other Non-Neoplastic Gastric Lesions Benign tumour and tumour- like lesions Gastrointestinal Stromal Tumour |
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NORMAL HISTOLOGY OF ESOPHAGUS AN APPROACH TO THE REPORTING OF ESOPHAGEAL BIOPSIES BARRETT'S ESOPHAGUS (INTESTINAL METAPLASIA DYSPLASIA & ADENOCARCINOMA) BENIGN TUMOURS AND TUMOUR - LIKE CONDITIONS OF ESOPHAGUS 1. SQUAMOUS PAPILLOMA OF THE ESOPHAGUS 2. INFLAMMATORY FIBROID POLYP OF THE ESOPHAGUS |
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Clinical
significance of gastric xanthoma:
This lesion may be confused with a
malignant tumour. Associated with pathological lesions such as chronic gastritis & intestinal metaplasia, atrophic gastritis, and gastric ulcer . Lipid islands are more common in certain conditions, such as diabetes mellitus, cholesterolosis of the gallbladder, obesity, and arteriosclerosis. Visit: Dermatopathology Case 30 Age & sex : More frequent in women and its incidence increases with age. Site: Usually located at the antral and the lesser curvature, but occasionally present in the body or fundus. These lesions are rare in other parts of the gastrointestinal tract. Cases have been reported in the small intestine, esophagus, and large intestine. Gross: Single or multiple, round to oval shaped well circumscribed, pale yellow nodule or plaque (1 - 2 mm in diameter). Microscopic features : Collection of mature lipid laden macrophages within the lamina propria.
Image
Link1 Visit: Verruciform Xanthoma ; Xanthelasma Differential diagnosis: Signet ring carcinoma : Isolated tumour cells may be present in the lamina propria . The tumour is positive for mucicarmine and cytokeratin. Gastric xanthoma: Positive with Sudan black, oil red O (on frozen section), and CD68, and are negative for PAS/alcian blue, mucicarmine and cytokeratin. Clear cell carcinoid tumour of stomach : Chromogranin A positive. Packaged appearance of the cells and vascular stroma in xanthoma may mimick neuroendocrine tumour. Whipple disease and Mycobacterium auium-intracellulare are rare infections of the stomach. Special stains (periodic acid Schiff with diastase and acid-fast bacilli) helps in establishing the diagnosis. |
| Abstracts:
Xanthelasmas of the upper gastrointestinal tract. J Gastroenterol. 2004;39(3):215-9.
Helicobacter pylori infection in
gastric xanthomas: immunohistochemical analysis of 145 lesions.Pathol
Int. 1996
Aug;46(8):589-93. Gastric xanthelasma in hyperplastic gastric polyposis. Arch Pathol Lab Med 1989; 113: 428-430 Gastric xanthoma.Am J Gastroenterol. 1976 Apr;65(4):311-7.
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External Links
1.
IMAGE LINK: click here (AFIP)
2.
IMAGE LINK (endo.) click
here (Gastrolab)
Normal histology of the small intestine for anatomic pathologists An approach to evaluation of small intestinal biopsy. Malabsorption syndrome (causes and clinical investigations) Enteropathy-associated T-cell lymphoma
Lesions causing small bowel
obstruction and bleeding - |
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- Normal
Histology of the Large Intestine - Interpretation of Large Intestinal Biopsies - Assessment of abnormalities -1 (lumen, surface epithelium, subepithelial zone) - Assessment of abnormalities - 2 (crypt density , architecture and epithelium) - Assessment of abnormalities - 3 (changes in the lamina propria,muscularis mucosae and submucosa) |
Classification of Soft Tissue Tumour
Gross examination of soft tissue specimen
A practical approach to histopathological reporting of soft tissue tumours