www.histopathology-india.net/GIPath.htm

Glycogenic acanthosis of the esophagus is a common benign entity, characterized by multifocal plaques of hyperplastic squamous epithelium with abundant intracellular glycogen deposits.

It has been reported in patients with Cowden's syndrome.

This lesion has no malignant potential.

Site - Lower third of the esophagus.

Gross - Multiple uniformly sized oval or round plaques usually less than 3 mm, are present in the crests of the longitudinal folds of the esophagus.

   Endoscopic Image ;    Gross Image Link

Microscopic features: Image

The superficial squamous epithelial layers are thicker than normal and contain  large cells with pale or clear cytoplasm filled with glycogen.

Abstracts:

Celiac disease and glycogenic acanthosis: a new association?Acta Paediatr. 2004;93(4):568-70.

Diffuse esophageal glycogenic acanthosis: an endoscopic marker of Cowden's disease.Am J Gastroenterol. 1997 Jun;92(6):1038-40.

Glycogenic acanthosis of the esophagus and gastro-esophageal reflux.J Clin Gastroenterol.1993;17(1):79-83

Glycogenic acanthosis of the esophagus: radiographic and pathologic features.Gastrointest Radiol. 1984;9(2):93-8.

Glycogenic acanthosis of the esophagus.AJR Am J Roentgenol. 1982 Oct;139(4):683-8.

Glycogenic acanthosis of the esophagus. A benign but confusing endoscopic lesion.Am J Gastroenterol. 1980 Sep;74(3):261-3.

Soft Tissue Pathology; Myxoid Tumours of Soft Tissue ;  Classification of Soft Tissue Tumour;  Gross examination of soft tissue specimen ;  A practical approach to histopathological reporting of soft tissue tumours ;  Grading of soft tissue tumours ; Lipomatous tumours ;Neural tumours ; Myogenic tumours ;Vascular tumours ; Fibroblastic/ Myofibroblastic tumours ; Myofibroblastic tumours ;  Fibrohistiocytic tumours ; ChondroOsseous tumours ; Soft TissueTumours of Uncertain Differentiation ; Notochordal Tumour -Chordoma ;Extra-adrenal Paraganglioma ; Gastrointestinal Stromal Tumour ;