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Pathology of Glycogenic


Dr Sampurna Roy MD  



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Glycogenic acanthosis of the esophagus is a common benign entity, characterized by multifocal plaques of hyperplastic squamous epithelium with abundant intracellular glycogen deposits.

It has been reported in patients with Cowden's syndrome.

This lesion has no malignant potential.

Site - Lower third of the esophagus.

Gross - Multiple uniformly sized oval or round plaques usually less than 3 mm, are present in the crests of the longitudinal folds of the esophagus.

Microscopic features- 

The superficial squamous epithelial layers are thicker than normal and contain large cells with pale or clear cytoplasm filled with glycogen.


Further reading

Celiac disease and glycogenic acanthosis: a new association?

Diffuse esophageal glycogenic acanthosis: an endoscopic marker of Cowden's disease.

Glycogenic acanthosis of the esophagus and gastro-esophageal reflux.

Glycogenic acanthosis of the esophagus: radiographic and pathologic features.

Glycogenic acanthosis of the esophagus.

Glycogenic acanthosis of the esophagus. A benign but confusing endoscopic lesion.


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Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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