Glycogenic
acanthosis of the esophagus is a common benign entity, characterized by
multifocal plaques of hyperplastic squamous epithelium with abundant
intracellular glycogen deposits.
It has been
reported in patients with Cowden's syndrome.
This lesion
has no malignant potential.
Site
- Lower third of the
esophagus.
Gross -
Multiple uniformly sized oval or round plaques usually less than 3 mm,
are present in the crests of the longitudinal folds of the esophagus.
Endoscopic Image ;
Gross Image Link
Microscopic
features: Image
The superficial squamous epithelial layers are thicker than normal and
contain large cells with pale or clear cytoplasm filled with
glycogen. |