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Vascular Tumours

Pathology of Hemangioendothelioma         

Dr Sampurna Roy MD





The term ' haemangioendotheliomata ' was introduced by Mallory FB. (J Exp Med 1908; 10 : 575-593) to include all 'tumours arising from blood vessel endothelium' and this term was not associated with the clinical behaviour of the tumours.

Stout AP (Ann Surg 1943; 118: 445-464) described the microscopic appearances of malignant tumours of blood vessels and linked the term hemangioendothelioma to malignant behaviour.

Later, Enzinger FM, Weiss SW (Soft tissue tumour, 2nd ed 1988: 533-544) described hemangioendotheliomas as vascular tumours of intermediate, borderline or low grade malignancy.

The term "hemangioendothelioma"  has been used to designate various groups of vascular tumours. 

Some of these entities are benign non- neoplastic reactive lesions. 


Benign infantile hemangioendothelioma  (cellular hemangioma of infancy)

Masson's vegetant intravascular hemangioendothelioma (intravascular endothelial hyperplasia)

Spindle cell  hemangioendothelioma / hemangioma

Kaposiform hemangioendothelioma (locally aggressive)

Low-Grade or Borderline Malignant Tumour: 

Retiform hemangioendothelioma 

Pseudomyogenic (Epithelioid Sarcoma - like) Hemangioendothelioma

Composite hemangioendothelioma 

Polymorphous  hemangioendothelioma

Dabska's Malignant Endovascular Papillary -Angioendothelioma

Malignant Tumour:

Epithelioid hemangioendothelioma



Further reading  

Hemangioendotheliomas-evolution of a concept of a heterogeneous group of vascular neoplasms.


Vascular tumours of the skin: A selective review

Cutaneous vascular proliferations. Part III. Malignant neoplasms, other cutaneous neoplasms with significant vascular component, and disorders erroneously considered as vascular neoplasms.

Primary vascular tumors of lymph nodes other than Kaposi's sarcoma. Analysis of 39 cases and delineation of two new entities.






Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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