HISTOPATHOLOGY INDIA.COM

   Malignant Sweat Gland  Tumours

     Dr Sampurna Roy MD  

 
Web www.histopathology-india.net
 
   Skin Appendage Tmour

       

http://www.histopathology-india.net/SAClass.htm

June 2007

                     
There is no universally accepted classification of hair follicle tumours. 

[ Further reading:

Hair follicle tumors of the skin. A review. Am J Pathol 1976;85:480-505.

Hair follicle tumors of skin. J Cutan Pathol 1985;12:189-195.

A review and proposed new classification of benign acquired neoplasms with hair follicle differentiation. Am J Dermatopathology 1990;12:496-516.  ]

It is often possible to identify the predominant type of follicular differentiation: eg outer root sheath, hair germ, infundibular etc. The tumours can be classifed depending on which part of the hair follicle the lesion differentiates toward or most closely resembles.

HAIR FOLLICLE DIFFERENTIATION:

Hair follicle infundibulum-  Keratinous cystic structures

Outer root sheath- Clear cells, peripheral palisading and hyaline basement  membrane.

Follicular germ with mesenchyme- Papillary mesenchymal bodies

Follicular bulb -
Cells of hair matrix included.

                            

CLASSIFICATION:

Hair Germ Differentiation:

Trichoepithelioma 
Desmoplastic Trichoepithelioma
Trichofolliculoma
Trichoblastoma
 
Cutaneous lymphadenoma

(variant of trichoblastoma)

                          
    
Infundibular differentiation:

Trichoadenoma
Dilated Pore of Winer
Pilar Sheath Acanthoma
Tumour of Follicular Infundibulum

Outer root sheath differentiation:
                    
Trichilemmoma

Trichilemmal Carcinoma

Proliferating Trichilemmal Cyst (Pilar Tumour)

Matrical differentiation:
                  
Pilomatrixoma and Pilomatrix Carcinoma
                  

Follicular mesenchymal differentiation:

Trichodiscoma ; Fibrofolliculoma(Dr. Weems) ; Perifollicular fibroma(Dr. Weems) ; Neurofollicular hamartoma

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Sebaceous tumours

Fordyce's Spots

Steatocystoma

Nevus Sebaceous

Folliculosebaceous Cystic Hamartoma

Sebaceous Hyperplasia

Sebaceoma

Sebaceous Adenoma

Sebaceous Carcinoma

     DermPath-India

     Site created by

 Dr Sampurna Roy MD

          

http://www.histopathology-india.net/dermpath.htm

Benign sweat gland tumours

Cysts:

Hydrocystoma -Eccrine/Apocrine

Hamartomas:

Eccrine/Apocrine naevus

Eccrine Angiomatous Hamartoma

Porokeratotic eccrine ostial naevus

Benign Neoplasms:

Syringocystadenoma Papilliferum

Hidradenoma Papilliferum

Nipple Adenoma

Syringoma

Spiradenoma

Cylindroma

Chondroid Syringoma (benign mixed tumour)

Poroma

Hidradenoma

Apocrine adenoma

Papillary eccrine adenoma

Syringofibroadenoma

Malignant sweat gland tumour 

Low grade:

Microcystic adnexal carcinoma

Eccrine epithelioma

Adenoid cystic carcinoma

Mucinous carcinoma

Primary extramammary Paget’s disease

Intermediate grade:

Porocarcinoma

Digital papillary adenocarcinoma

High grade:

Hidradenocarcinoma

Apocrine adenocarcinoma

Eccrine ductal carcinoma

Spiradenocarcinoma

Malignant cylindroma