Clear cell hidradenoma,
solid and cystic hidradenoma or dermal acrospiromas.
Hidradenoma is a benign dermal appendage tumour. Hidradenomas may be of eccrine or
often partly solid, partly cystic.
Located in any
part of the body. There is a
slight predilection for the head,
face, and upper extremities.
Well-circumscribed dermal tumor with a grenz zone between the tumour and the
epidermis ; Variously shaped tumour
islands in the dermis ; May extend into the subcutis ;
Combination of solid and cystic areas ;
Cystic spaces form as
a result of tumour cell degeneration ; The intervening stroma varies from delicate
vascularized fibrous tissue to dense hyalinized collagen ;
epidermal connection may be present ; Foci of squamous
differentiation; Ductal differentiation and intracytoplasmic
lumina ; Mitotic figures are often present which is of little
Two types of cells
cell type is polyhedral with a rounded nucleus and slightly
basophilic cytoplasm. The second cell type is generally round with
Clear cell ;
Poroid ; Oncocytic ; Epidermoid, and Pigmented.
Images of Clear cell Hidradenoma
Images of Poroid Hidradenoma:
hidradenomas are characterized by prominent clear
cells which is present in less than one third of hidradenomas.
Mucus producing cells are found in some cases. The clear
cells contain glycogen and periodic acid-Schiff-positive,
diastase-resistant material, but no lipid.(Dr
Poroid hidradenomas are well circumscribed ,
non-encapsulated tumours composed of predominantly poroid cells. Cytologically this
variant resembles an eccrine poroma.
Atypical hidradenomas- cytological atypia or
infiltrative margins; higher rate of recurrence and malignancy.
The significance of atypical nuclear changes
in benign eccrine acrospiromas: a clinical and pathological study
of 18 cases.J
Cutan Pathol. 1984 Feb;11(1):35-44.
hidradenoma can recur after inadequate excision.
It is sometimes
difficult to distinguish solid cellular hidradenomas without
duct-like structures and
glomus tumour without a vascular pattern.
Clear cell tumours of skin
Hidradenocarcinoma: click here .
(Clear cell hidradenoma: a
mimic of metastatic clear cell tumors.
Arch Pathol Lab Med.