Lichenoid (Interface) Tissue Reaction
Images of Lichen Planus and diagram of variants of Lichen Planus :
Visit: Lichen planus-like lesions
Interface dermatosis is a common form of inflammatory dermatosis.
A wide range of inflammatory skin diseases exhibit interface change with considerable overlap of histological features.
The term "lichenoid" is avoided by some pathologists because of clinical
and histological difference in the definition of this term.
The following features are characteristic of Interface Dermatitis:
This feature is essential to make a diagnosis of an interface dermatitis.
II- Vacuolar or hydropic change due to basal cell degeneration.
III- Colloid or civatte bodies are eosinophilic bodies formed as a result of apoptosis.
These may be present in the lower part of the epidermis (suprabasal) or in the dermis.
IV- Pigment incontinence due to damage of basal keratinocytes and melanocytes.
Interface dermatitis is divided into five groups-
II- Vacuolar (Erythema Multiforme-like) Reaction:
Example- Erythema Multiforme ; Toxic epidermal necrolysis ; Acute graft vs host disease (Cutaneous lesions in graft versus host disease) ; Pityriasis lichenoides ; Lupus erythematosus (acute & subacute) ; Fixed drug eruption (Drug induced cutaneous lesions).
III- Atrophic (Poikilodermatous) Reaction:
Example- Atrophic lichen planus ; Systemic lupus erythematosus ; Dermatomyositis ; Mycosis Fungoides.
IV- Interface Reactions with Irregular Epidermal Hyperplasia:
Example: Hypertrophic lichen planus ; Rare lichenoid drug eruptions ; Verrucous lupus erythematosus.
V- Interface Reactions with Psoriasiform Hyperplasia:
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