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Pathology of Infective


Dr Sampurna Roy MD         




Infection-induced panniculitis may result from a number of microbes including bacteria, fungi, and parasites.

Viruses have also been implicated as a cause.

Infectious agents and infestations can lead to lobular or mixed lobular and septal panniculitis.

This type of panniculitis can occur as a primary infection by direct inoculation of infectious microorganisms into the subcutaneous tissue, or secondarily via microbial hematogenous dissemination with subsequent infection of the subcutaneous tissue.

The various organisms include candidiasis, cryptococcus, mycetoma, actinomycosis, nocardiosis, chromomycosis, sporotrichosis and histoplasmosis, infections with Mycobacterium Marinum , Mycobacterium Ulcerans , M.fortuitum, Mycobacterium Tuberculosis, Mycobacterium Leprae (erythema nodosum leprosum) and Mycobacterium Avium Intracellulare .

Other bacterial organisms, bites of ticks  and  infective conditions like myasis, cysticercosis, sparganosis and infestations by certain helminths may also cause panniculitis.

Most cases of infection-induced panniculitis occur in patients who are immunosuppressed.


The presence of a lobular or mixed lobular and septal panniculitis in which there is a heavy infiltrate of neutrophils, often with extension into the dermis, should raise the suspicion of an infective etiology.

Hemorrhage and necrosis are often present. 


Further reading:

Atypical nodular panniculitis.

Histoplasmosis and subcutaneous nodules in a kidney transplant recipient: erythema nodosum versus fungal panniculitis.

Infection and panniculitis.

Infective panniculitis.

Panniculitis, infection, and dermatomyositis: case and literature review.

Brucellosis presenting as septal panniculitis with vasculitis.

Recurrent eosinophilic panniculitis associated with Fasciola hepatica infection.

Cryptococcal panniculitis in an immunocompromised patient

Histopathology of a granulomatous lobular panniculitis

Mycobacterium-associated lobular panniculitis




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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