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- Normal
Histology of the Large Intestine - Interpretation of Large Intestinal Biopsies - Assessment of abnormalities -1 - Assessment of abnormalities - 2 (crypt density , architecture and epithelium) - Assessment of abnormalities - 3 (changes in the lamina propria,muscularis mucosae and submucosa) |
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Pathology
of the Intestinal Polyps
Gross examination of polypectomey
specimens |
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Pulmonary Pathology Online Normal Anatomy and Histology of the Lung and Airways Histopathological reporting of pulmonary parenchymal biopsies Closed pleural biopsy for neoplasm or inflammatory lesions Open pleural biopsy and pneumonectomy or pleural stripping Congenital Cystic Adenomatoid Malformation Acute Respiratory Distress Syndrome Neonatal Respiratory Distress Syndrome Complications of Neonatal Respiratory Distress Syndrome Chronic Obstructive Pulmonary Disease Emphysema Bronchiolitis Pulmonary Alveolar Proteinosis Other forms of Pulmonary Embolism Pulmonary Collapse (Atelectasis) and Pneumothorax Pulmonary EdemaPulmonary Hemorrhage (Eg. Goodpasture's Syndrome) Primary Pulmonary Leiomyosarcoma Primary Pulmonary Rhabdomyosarcoma Primary Monophasic Synovial Sarcoma of the Lung Pulmonary Malignant Fibrous Histiocytoma Neurogenic Tumours of the Lung Intrapulmonary Solitary Fibrous Tumour Localized Fibrous Tumour of the Pleura Pulmonary Lymphoproliferative Disease Post-Transplant Lymphoproliferative Disease |
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B-CELL LYMPHOMA :
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MALTOMA : Gastric Lymphoma: click T- CELL LYMPHOMA:
-CELIAC
ENTEROPATHY ASSOCIATED : click
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Gastrointestinal tract is the most common
site of primary extranodal lymphoma . Lymphoma accounts for 30% of small
bowel malignancies.
Primary gastrointestinal lymphoma exhibits no evidence of liver, spleen or bone marrow involvement at the time of diagnosis. Regional lymphnode involvement may be present.
Criteria used to classify malignant lymphoma of small bowel include: ii) Primary or systemic nature of tumour iii)Associated backround chronic illnesses. Primary gastrointestinal lymphoma usually arise as a sporadic tumour. Sporadic lymphomas, also termed the 'Westerm type' are B- cell lymphomas which appear to arise from the B- cells of the mucosa associated lymphoid tissue. Some lymphomas develop in the backround of chronic diseases . Eg. Sprue -like malabsorption syndromes, congenital immunodeficiency states, infection with HIV following organ transplantation with immunosuppresion (heart transplant recipients), those complicating Crohn's disease , hypogammaglobulinaemia with lymphoid hyperplasia, in patients with alpha chain disease. Ileum is commonly affected followed by jejunum and duodenum. |
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Immunoproliferative small
intestinal disease, / Mediterranean lymphoma:
B-cell lymphoma usually arises in
children and young adults with Mediterranean ancestry. |
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Burkitt's lymphoma
of small bowel:
-Relatively common in the Middle east and Algeria. |
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Mantle cell
lymphoma of small bowel:
Presents as lymphoid polyps in elderly patients (around 60
years of age). |
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Follicular lymphoma
of the small bowel:
The tumour has a follicular growth pattern and consists |
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Gastrointestinal lymphomas of T and B cell types. Mod Pathol.1999; 12(2): 151- 8 Extranodal lymphomas: the MALT concept. Verh Dtsch Ges Pathol.1992 ;76:14-23 abstract |
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- Lymphoid
hyperplasia of small intestine is a reactive process.
- Usually located at the ileocecal junction. - Clinically the patients present with right iliac fossa pain, obstruction and sometimes intussusception. - Associated with viral infection in children. - Diffuse nodular lymphoid hyperplasia is present in some patients of primary hypogammaglobulinemia. - Giardia lamblia infection is noted in some patients with lymphoid hyperplasia. - D/D: Malignant lymphoma: Immunohistochemistry is performed to confirm the diagnosis |
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ABSTRACTS Lymphoid hyperplasia of the intestine in children. 15 cases. Ann Pediatr (Paris)1992; 39(6): 359-64
Florid reactive lymphoid
hyperplasia of the terminal ileum in adults. A condition bearing a close
resemblance to low-grade malignant lymphoma. Histopathology 1990;17:
19-26
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IMAGES
Immunoproliferative small intestinal disease
Mantle cell lymphoma
Follicular lymphoma of
terminal ileum
Burkitt's lymphoma
of small intestine
Lymphoid hyperplasia of small bowel
(pseudolymphoma)
Normal histology of the small intestine for anatomic pathologists An approach to evaluation of small intestinal biopsy. Malabsorption syndrome (causes and clinical investigations) Enteropathy-associated T-cell lymphoma
Lesions causing small bowel
obstruction and bleeding - |
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Myxoid
Tumours of Soft Tissue Classification of Soft Tissue Tumour Gross examination of soft tissue specimen A practical approach to histopathological reporting of soft tissue tumours Grading of soft tissue tumours Fibroblastic/Myofibroblastic tumours |