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Exfoliative Pulmonary Cytology-

Features of Large Cell Carcinoma

Dr Sampurna Roy MD                                  April 2015   


Image: Bronchial brushing-Large cell carcinoma- Groups of large pleomorphic cells with variable cytoplasm.

1. More readily classified histologically usually as squamous or adenocarcinoma, or unusually as large cell neuroendocrine carcinoma.

2. Large pleomorphic obviously malignant cells, arranged singly and in sheets.

3. Poorly formed cytoplasm, vesicular chromatin, large nucleoli.

4. Necrosis may be present.

 

Further reading:

Cytological characteristics of pulmonary large cell neuroendocrine carcinoma.

Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma.

Diagnostic findings of bronchial brush cytology for pulmonary large cell neuroendocrine carcinomas: comparison with poorly differentiated adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.

Large-cell neuroendocrine carcinoma of the lung: proposed criteria for cytologic diagnosis.

Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology.

Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma.

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 

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