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 Dr Sampurna Roy MD

http://www.histopathology-india.net/dermpath.htm

Glossary   

Gross examination of the skin specimen

Reporting of biopsies taken for Inflammatory Skin Diseases

Lichenoid (Interface)Tissue Reaction Pattern

Psoriasiform Reaction Pattern

Vesiculobullous Reaction Pattern

Spongiform Reaction Pattern

Vasculopathic Reaction Pattern

Lichen planus-like lesions

Bullous Pemphigoid

Dermatitis Herpetiformis

Hailey-Hailey Disease

Erythema Nodosum

Folliculitis

Impetigo

Furuncle(Boil)

Carbuncle

Toxic Shock Syndrome

Drug related cutaneous lesions

Cutaneous lesion in graft-
versus host disease

Calcinosis Cutis

Cutaneous Ossification (Osteoma Cutis)

Cartilaginous lesions of skin

Lipoid Proteinosis

Pathology of Colloid Milium

Gout

Silicone granulomas

Xanthelasma

Granuloma Annulare

Necrobiosis Lipoidica

Necrobiotic Xanthogranuloma   

Rheumatoid Nodule

Lupus Vulgaris

Cutaneous Sarcoidosis

Melkersson Rosenthal Syndrome

Annular Elastolytic Giant Cell Granuloma

Skin lesion in Crohn's Disease

Blastomycosis-like pyoderma

Foreign body granuloma

Rosacea

Interstitial Granulomatous Dermatitis

Interstitial Granulomatous Drug Reaction

Granulomatous T-cell lymphoma

Skin Adnexal Tumours

Tumours of the Hair Follicle

Sebaceous tumours

Primary Cutaneous Lymphoma

Lymphomatoid papulosis

Role of immunohistochemistry in Dermatopathology 

Verruca vulgaris;

Keratoacanthoma

Actinic Keratosis

Bowen's disease

Basal Cell Carcinoma

Squamous Cell Carcinoma

Cutaneous Squamous Cell Ca.

Benign Sweat Gland Tumours

Apocrine/ Eccrine Hidocystoma

Hamartomas

Chondroid syringoma

Syringoma

Syringocystadenoma Papilliferum   

Lichen nitidus is a rare benign chronic papular lesion of unknown etiology. It was originally regarded as a variant of lichen planus but it is now considered a distinct entity.

Clinical presentation:   Multiple , small flesh-coloured papules. These are 1-2 mm in diameter.

Clinical images(DermAtlas)

Clinical variants: Generalized, actinic, perforating , linear, vesicular etc.  

Age: Usually present in children and young adult males.

Site: Upper extremities, chest, abdomen, genitalia. Rarely palms, soles and nails may be involved.

Microscopic features:  Image Link1 ; Image Link2 ; Image Link3 ; Image Link4

Dense, well circumscribed subepidermal infiltrate.

Limited to one or two adjacent dermal papilla.

Claw-like downgrowths of the rete ridges are present at the margins of the infiltrate.

Inflammatory cells push against the undersurface of the epidermis.

Inflammatory infiltrate consists of lymphocytes, histiocytes, melanophages, plasma cells in some cases, a few epithelioid cells and occasional giant cells.

Differential diagnosis:

Disseminated granuloma annulare ;  Early lesion of lichen scrofulosorum (granulomas in lichen scrofulorum do not cause widening of the papillae) ; Giant cell lichenoid dermatitis: a possible manifestation of sarcoidosis ;  Lichenoid and granulomatous dermatitis ;  Micropapular sarcoidosis simulating lichen nitidus.

Condyloma with lichen nitidus. Skin med. 2005 May-Jun;4(3):177-8.

Generalized lichen nitidus.Pediatr Dermatol. 2005 Mar-Apr;22(2):158-60

Palmoplantar lichen nitidus: a rare cause of palmoplantar hyperkeratosis Ann Dermatol Venereol. 2004 Aug-Sep;131(8-9):822-4.

Periappendageal lichen nitidus: report of a case.J Cutan Pathol 2002;29:125-128

Generalized lichen nitidus.Clin Exp Dermatol. 2002 Mar; 27 (2):115-7.

Crohn's disease and lichen nitidus: a case report and comparison of common histopathologic features.Inflamm Bowel Dis. 2001 Nov;7(4):314-8.

Lichen nitidus of the palms: a case with peculiar histopathologic features.Am J Dermatopathol. 1999 Apr;21(2):161-4.

Generalized lichen nitidus: case report and literature review. Cutis 1999 Aug;64(2):135-6

Generalized lichen nitidus with oral and nail involvement in a child.Dermatology 1997;194(4):367-9

Generalized lichen nitidus appearing subsequent to lichen planus. J Dermatol 1995 Jun;22(6):434-7

Erythema nodosum, lichen planus and lichen nitidus in Crohn's disease: report of a case and analysis of T cell receptor V gene expression in the cutaneous and intestinal lesions..Dermatology 1995;190(1):59-63

A case of generalized lichen nitidus with Koebner's phenomenon. J Dermatol 1994 Apr;21(4):273-7

Perforating lichen nitidus.Int J Dermatol. 1994 May;33 (5) :382-4.

Immunohistochemical examination of lichen nitidus suggests that it is not a localized papular variant of lichen planus.J Am Acad Dermatol. 1992 Aug;27(2 Pt 1):232-6.

Lichen nitidus: a histologic and electron microscopic study. J Dermatol 1991 Aug;18(8):47

An immunophenotypic study of lichen nitidus.Clin Exp Dermatol 1990 Jul;15(4):273-6

Lichen nitidus: electron microscopic and immunofluorescence studies .Acta Derm Venereol 1982;62(1):15-9

Inflammatory diseases of the Eyelid

Tumour and tumour-like lesions of the Eyelid

Adnexal Tumours of the eyelid

Epidermal tumours of the Eyelid

Mesenchymal Tumours of the Eyelid

Melanocytic tumours of the Eyelid

Histopathological patterns in cutaneous infections

1: Bacterial, Rickettsial and Chlamydial infection

2 : Spirochetal Infection

3 : Mycoses and algal infections

4 : Protozoal Infections

5 : Helminth Infections

6 : Viral Infections

Cutaneous lesion associated
with AIDS

Epidermal tumours

Prurigo Nodularis

Acanthomas 

Clear cell acanthoma

Large cell acanthoma

Warty Dyskeratoma

Seborrheic Keratosis