Lymphocytic
gastritis is associated with coeliac disease (specially antral
prdominant gastritis) and non-coeliac small intestinal intraepithelial
lymphocytosis with malabsorption.
- Lymphocytic gastritis is also associated with Helicobacter pylori
infection (specially corpus predominant lymphocytic gastritis).
- Eradication of H. pylori plays an important role in the treatment of
lymphocytic gastritis.
- In the severe form lymphocytic gastritis is diagnosed as varioliform
gastritis.
Endoscopic
features :
Enlarged mucosal folds, multiple, discrete mucosal nodules or plaques
with central umbilications , erosions or apthoid ulcers and surrounding
hyperemia.
Microscopic
features:
-Intraepithelial T cells (CD8 positive) in the surface and superficial
pit epithelium.
-Intraepithelial lymphocytes are scattered rather than in clusters.
-The glands are spared. The pits have a corrugated dilated appearance.
-There should be atleast 25 lymphocytes/100 epithelial cells to make a
diagnosis.
-The intraepithelial lymphocytes create a vacuolated or clear cell
appearance (subnuclear region).
Differential
diagnosis:
Pathologists
should be able to distinguish lymphocytic gastritis from B-cell
lymphoepithelial lesions seen in MALT lymphomas.
Visit: Gastric Lymphoma
IMAGE
LINK(Greeson)
; CASE
LINK (AFIP) |