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Pathology of Malignant


Dr Sampurna Roy MD                          



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Dr Sampurna Roy MD



July 2014

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

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Targetoid  hemosiderotic hemangioma

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It is as a rare soft tissue sarcoma showing two or more distinct types of malignant mesenchymal differentiation.

It is generally thought that malignant mesenchymomas are high grade sarcomas with a poor prognosis.

However, low grade malignant mesenchymomas have been reported which had a better prognosis.

It is essential to study all areas of the tumour by means of immuno-histochemistry for an accurate histological diagnosis of malignant mesenchymoma.

Age: Mainly adults.

Site: These tumours are frequently located in the trunk (for example, the chest wall and retroperitoneum) and lower extremities (usually on the thigh).

Microscopic features: Consists of 3 most common components: 

 1. Liposarcoma ; 2. Rhabdomyosarcoma ; 3. Osteosarcoma

Myoblastic components in malignant mesenchymoma are not dedifferentiated and other distinct mesenchymal components such as regions of liposarcoma , chondrosarcoma, and osteosarcoma are neoplastic, regardless of their histological grades.

Differential diagnosis:

Mesenchymal tumours with two or more phenotypes-  i) Malignant Triton tumours ; ii) liposarcoma with smooth muscle, cartilaginous, or osseous differentiation;  iii) dedifferentiated liposarcoma and iv) dedifferentiated chondrosarcoma.

Visit: Soft tissue tumours of uncertain differentiation


Further reading:

Combined Pleomorphic Liposarcoma and Osteosarcoma of the Soft Tissue: A Tale of Malignant Mesenchymoma?

Recurrent pericarditis revealing a malignant mediastinal mesenchymoma.

Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone.

Primary osteochondrorhabdomyosarcoma (malignant mesenchymoma) of the fibula: a rare tumour in an unusual site case report and review of the literature.

Malignant mesenchymoma of the pleura

Malignant mesenchymoma arising from a uterine leiomyoma in the menopause.

Malignant mesenchymoma of the lower leg.

Malignant mesenchymoma.

Malignant mesenchymomas of soft tissue associated with numerous osteoclast-like giant cells mimicking the so-called giant cell variant of "malignant fibrous histiocytoma".

Malignant mesenchymoma. Clinicopathologic analysis of a series with evidence of low-grade behaviour.

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Vascular tumours

Lipomatous tumours

Myxoid Tumours of Soft Tissue

Soft Tissue Tumours of Uncertain Differentiation           

Intramuscular Myxoma

Aggressive Angiomyxoma

Synovial Sarcoma

Alveolar Soft Part Sarcoma

Epithelioid Sarcoma

Clear cell sarcoma & PEComas

Extraskeletal Ewing's Sarcoma / PNET

Desmoplastic small round cell tumour

Pleomorphic hyalinizing angiectatic tumour

Mixed tumour, myoepithelioma, parachordoma

Ectopic hamartomatous thymoma

Extra-renal rhabdoid tumour


Vascular tumours


Lobular capillary hemangioma (pyogenic granuloma

Bacillary angiomatosis

Verruga Peruana

Acro-angiodermatitis / pseudo-Kaposi's  sarcoma

Reactive angio endotheliomatosis

Infantile Hemangioma

Glomeruloid hemangioma 

Acquired tufted angioma

Verrucous hemangioma

Cherry angioma/senile angioma

Arteriovenous hemangioma 

Microvenular hemangioma

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