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Pathology of Nipple Adenoma-

(Erosive Adenomatosis or Florid Papillomatosis)

Dr Sampurna Roy MD         


Path Quiz Case 23: Case history and images:

Diagnosis: Nipple Adenoma





Syn. : Erosive adenomatosis, papillary adenoma, florid papillomatosis.

Adenoma or florid papillomatosis of the nipple is a rare, benign neoplasm of  breast lactiferous ducts, clinically frequently misdiagnosed as Paget's disease.

Clinical presentation:

Papillary adenoma of the nipple typically occur in a female patient as an erosion, ulceration, or mass that is sometimes accompanied by serous or bloody discharge from the nipple.

The lesion is usually unilateral and less than 1 cm in diameter.


Microscopic features: 


Histologically, this is a well-defined lesion in the nipple dermis composed of ducts similar to breast.

Some of these ducts have papillary projections into the lumen.

Epithelial hyperplasia may be present.

There may be variable amounts of sclerosis, apocrine metaplasia or squamous metaplasia.

Syringomatous pattern may be noted in some cases. These lesions are histologically similar to microcystic adnexal carcinoma.


Differential diagnosis:

Papillary adenoma of the nipple is often histologically misinterpreted as syringocystadenoma papilliferum, hidradenoma papilliferum, or low-grade adenocarcinoma.


Further reading

Superficial papillary adenomatosis of the nipple: a rare disease diagnosed by sonography and histopathologically confirmed by nipple-preserving total excision.

Nipple adenoma arising from axillary accessory breast: a case report.

Nipple adenoma in a man: An unusual case report.

Erosive adenomatosis of the nipple.

Syringomatous adenoma occurring within a supernumerary nipple.

Adenoma of the nipple, focusing on the contrast-enhanced magnetic resonance imaging findings: report of a case.

Nipple adenoma of the breast: sonographic imaging findings.

Immunophenotype of nipple adenoma in a male patient.

Nipple adenoma in an adolescent.

Nipple adenoma of breast: a masquerader of malignancy.






Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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