Nodular Melanoma

Site created by

Dr Sampurna Roy MD

http://www.histopathology-india.net/dermpath.htm

Dr. Sampurna Roy MD

http://www.histopathology-india.MelanocyticTumours.htm

May 2007

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Melanocytic tumours

1. Acquired Melanocytic Naevus

Ancient Naevus
Halo naevus
Balloon cell naevus
Combined Naevus
Recurrent melanocytic naevus

2. Spindle and epithelioid cell naevi

Spitz naevus
Pigmented spindle cell naevus

3. Blue naevi

Common blue naevus
Cellular blue naevus

4. Dermal melanocytoses

Naevus of Ota
Naevus of Ito
Mongolian spot

5. Congenital melanocytic naevi
6. Dysplastic melanocytic naevi

Nodular melanoma is the second most common subtype of melanoma. It represents 15% of all melanomas.

The most common sites for nodular melanoma are the trunk, head, and neck.

The patients are usually in the fifth decade of life.

It is more common for nodular melanoma to begin in normal skin rather than in a pre-existing lesion.

Macroscopically, the lesion presents as a nodular, polypoid or pedunculated dark brown or blue black lesion. Lesion may also present as an amelanotic nodule. Image Link (DermAtlas)

Microscopic features: In nodular melanoma there is minimal or no radial growth phase. Image1; Image2
Histologically, the dermal component is usually composed of epithelioid type of cells . There is epidermal invasion directly over the dermal component . No adjacent intraepidermal component is seen.

Abstracts:

Clinicopathological features of melanocytic skin lesions in Egypt.Eur J Cancer Prev. 2006;15(1):64-8.

Melanoma simulating malignant soft tissue tumour.Cesk Patol. 2005;41(4):146-9.

CD34 expression in primary cutaneous malignant melanoma: apropos of a case and review of the aberrant melanoma phenotype.J Cutan Pathol. 2005;32(10):685-9.

BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival.J Invest Dermatol. 2005;125(2):312-7.

Breslow depth of cutaneous melanoma: impact of factors related to surveillance of the skin, including prior skin biopsies and family history of melanoma.J Am Acad Dermatol. 2005;53(3):393-406.

Pigmented melanocytic lesions causing diagnostic problems

Prognostic parameters of melanoma

Lentigo maligna melanoma

Superficial spreading melanoma

Nodular melanoma

Acral lentiginous melanoma

Desmoplastic /Spindle cell /
Neurotropic melanoma

Naevoid melanoma

Balloon cell melanoma

Pathology of the Eyelid
Inflammatory diseases of the Eyelid

Tumour and tumour-like lesions of the Eyelid

Adnexal Tumours of the eyelid

Epidermal tumours of the Eyelid

Mesenchymal Tumours of the Eyelid

Melanocytic tumours of the Eyelid