Pathology Quiz Online

           January 2005        Case - 41   

                        Dr  Sampurna Roy  MD    

          Clinical History:   A 65 year old female with a bullous lesion on the  flexure surface of the

        left upper arm.  

             Microscopic features : Skin biopsy in which the epidermis is flattened with no evidence of

         necrotic keratinocytes.    There is a large subepidermal bulla, the lumen of which contains numerous

         eosinophils together with a few lymphocytes and neutrophils enmeshed with fibrin.

         In areas the papillary dermis festoons into the blister cavity. The underlying dermis is oedematous

         and shows a patchy chronic inflammatory infiltrate.

                                         DIAGNOSIS: