Path Case50

Pathology Quiz Online

April 2005 Case - 50

Dr Sampurna Roy MD

Clinical History: A 61 year old male presented with a 3 month history of abdominal pain ,fever,

gastrointestinal tract bleeding and weight loss. There is splenomegaly and lymphadenopathy.

Lymphnodes are palpable in the cervical, axillary and inguinal region.

CT scan: Enlarged lymphnodes in the cervical, inguinal, retroperitoneal region, around aorta

and in the mediastinum. There is thickening of the caecum and right side of the colon.

             Colonoscopy: Revealed multiple grayish-white polypoid lesions 1.5 to 2.0 cm in diameter.

             These are endoscopic biopsy specimens from the lesions in the colon.

         Immunohistochemistry:
                                                         CyclinD1: shows strong nuclear positivity
                                                         CD5: Positive
                                                         CD20 & CD19: Positive
                                                         CD10 & CD23: Negative
                                                         CD3: Negative

DIAGNOSIS: