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Pathology Quiz Case - 50

 Dr Sampurna Roy MD

 

                                                                                                   

 

Clinical History: A 61 year old male presented with a 3 month history of abdominal pain , fever, gastrointestinal tract bleeding and weight loss.

There is splenomegaly and lymphadenopathy. 

Lymphnodes are palpable in the cervical, axillary and inguinal region.

CT scan: Enlarged lymphnodes in the cervical, inguinal, retroperitoneal region, around aorta and in the mediastinum. There is thickening of the caecum and right side of the colon.

Colonoscopy:  Revealed multiple grayish-white polypoid lesions 1.5 to 2.0 cm in diameter.

These are endoscopic biopsy specimens from the lesions in the colon.

Immunohistochemistry:  

CyclinD1: shows strong nuclear positivity

CD5: Positive

CD20 and CD19: Positive

CD10 and CD23: Negative

CD3: Negative

         

              

Diagnosis

 

Dart

 


 

 

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