Pathology Quiz Online

                                April 2005     Case - 50

                                                  Dr  Sampurna Roy  MD 

              Clinical History: A 61 year old male presented with a 3 month history of abdominal pain ,fever,   

             gastrointestinal tract bleeding and weight loss. There is splenomegaly and lymphadenopathy.

             Lymphnodes are palpable in the cervical, axillary and inguinal region.

             CT scan: Enlarged lymphnodes in the cervical, inguinal, retroperitoneal region, around aorta

             and in the mediastinum. There is thickening of the caecum and right side of the colon.

             Colonoscopy:  Revealed multiple grayish-white polypoid lesions 1.5 to 2.0 cm in diameter.

             These are endoscopic biopsy specimens from the lesions in the colon.

          Immunohistochemistry:
                                                         CyclinD1: shows strong nuclear positivity
                                                         CD5: Positive
                                                         CD20 & CD19: Positive
                                                         CD10 & CD23: Negative
                                                         CD3: Negative

                                            DIAGNOSIS: