Pathology of Polymorphous Hemangioendothelioma

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Pathology of Polymorphous Hemangioendotheliomas

2022

Polymorphous hemangioendotheliomas are rare, low-grade borderline malignant vascular tumours of endothelial cell origin.

Site: The tumour most frequently involves lymph nodes, but it can also affect extranodal locations like liver, spinal cord.

Microscopic features: Characterized by a variety of patterns within the same lesion.

- Solid areas with sheets of polygonal cells with scanty cytoplasm and minimal atypia;

- Vascular differentiation - cytoplasmic vacuoles, clefts, channels and papillary structures;

- Angiomatous areas with vascular spaces lined by endothelium with or without hobnail appearance.

Immunohistochemistry: UEA-1: positive ; von Willibrand factor: negative.

Differential diagnosis: Angiosarcoma (absence of anaplasia and dissecting vascular channels in polymorphous hemangioendothelioma)