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Vascular Tumours

Pathology of Polymorphous Hemangioendotheliomas

Dr Sampurna Roy MD          





Polymorphous hemangioendotheliomas are rare, low-grade borderline malignant vascular tumours of endothelial cell origin.

Site: The tumour most frequently involves lymph nodes, but it can also affect extranodal locations like liver, spinal cord.

Microscopic features:  Characterized by a variety of patterns  within the same lesion.

- Solid areas with sheets of polygonal cells with scanty cytoplasm and minimal atypia;

- Vascular differentiation - cytoplasmic vacuoles, clefts, channels and papillary structures;  

- Angiomatous areas with vascular spaces lined by endothelium with or without hobnail appearance.

Immunohistochemistry:   UEA-1: positive ;  von Willibrand factor: negative.

Differential diagnosis:  Angiosarcoma (absence of anaplasia and dissecting vascular channels in  polymorphous hemangioendothelioma)


Further reading:

Polymorphous hemangioendothelioma of the neck.

Primary polymorphous hemangioendothelioma of the spinal cord. Case report.

Polymorphous hemangioendothelioma.

Polymorphous hemangioendothelioma: a report of two cases, one affecting extranodal soft tissues, and review of the literature

Unique vascular tumor primary arising in the liver and exhibiting histopathological features consistent with so-called polymorphous hemangioendothelioma.

Nodal and extranodal soft tissue polymorphous hemangioendothelioma:a case report and review of the literature.

Polymorphous hemangioendothelioma in a child with acquired immunodeficiency syndrome (AIDS).






Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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