Gastrointestinal Stromal Tumour

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                                       HISTOPATHOLOGY INDIA.COM

  Atypical Fibroxanthoma

     Dr Sampurna Roy MD

 
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April 2007

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Normal histology of the small intestine for anatomic pathologists

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Whipple's disease
               
Etiology:

- Consumption of aspirin and other nonsteroidal
anti-inflammatory drugs.
- Chronic alcohol ingestion
- Alkaline or bile reflux(abnormal pyloric sphincter function,
previous surgical intervention)
- Uraemia
Microscopic features:
- Glandular elongation and tortuosity
- Mucin depletion
- Edema
- Hypercellularity of the gastric pits
- Foveolar hyperplasia
- Increased number of smooth muscle fibres in lamina propria.
- Villiform transformation of the mucosa
- Regenerative (basophilic) glands with increased mitotic activity.
-Capillary congestion and vasodilation in superficial lamina propria
- A few chronic inflammatory cells and occasional neutrophils.
- Usually there is no evidence of atrophy.
- Bile in the glands.
- Long standing bile reflux cases may be accompanied by erosions or intestinal metaplasia (including all its subtypes).
Note :  Reactive gastritis with erosions is the commonest cause of false positive diagnosis of dysplasia or carcinoma in the stomach.

                  

 
 
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Abstracts:
Bile reflux gastritis and intestinal metaplasia at the cardia. Gut.2002 Sept; 51(3):351-5

Reflux gastritis in gastroesophageal reflux disease: A histopathological study.Ann Diagn Pathol. 1999 Oct;3(5):281-6

Bile reflux and intestinal metaplasia in gastric mucosa.J Clin Pathol. 1993 Mar;46(3):235-40.

 Gastritis in patients on non-steroidal anti-inflammatory drugs. 
Histopathology 1993 ;23: 341-8 

Reflux gastritis in the intact stomach.  J Clin Pathol 1990 ;43: 303-6

Reflux gastritis: distinct histopathological entity?J Clin Pathol  1986 ;39: 524-30

 
Soft Tissue Pathology;

Myxoid Tumours of Soft Tissue ;  Classification of Soft Tissue Tumour;  Gross examination of soft tissue specimen ;  A practical approach to histopathological reporting of soft tissue tumours ;  Grading of soft tissue tumours ; Lipomatous tumours ;Neural tumours ; Myogenic tumours ;Vascular tumours ;Fibroblastic/Myofibroblastic tumours ; Myofibroblastic tumours ;  Fibrohistiocytic tumours ; ChondroOsseous tumours ; Soft TissueTumours of Uncertain Differentiation ; Notochordal Tumour -Chordoma ;Extra-adrenal Paraganglioma ; Gastrointestinal Stromal Tumour ;

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An outline of the anatomy and normal histology of the  stomach for pathologists.

Reporting of gastric biopsies (non-neoplastic gastric lesions).

Pathology and pathogenesis of peptic ulcer.

Acute Gastritis 

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Helicobacter pylori  associated(TypeB) Gastritis 

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Gastric Xanthoma/Xanthelasma

Other Non-Neoplastic Gastric Lesions

Benign tumour and tumour- like lesions

Gastric Lymphoma

Gastric Carcinoid Tumour

Gastrointestinal Stromal Tumour 

Gastric Epithelial Dysplasia

Early Gastric Carcinoma

Gross Examination of the Gastrectomy Specimen 

Drug related lesions of the gastrointestinal tract