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Superficial spreading melanoma may
develop in any part of the body and at any age.
It
is commonly noted on the trunk and lower extremities.
Macroscopically, the lesion has a variegated colour and an expanding
irregular margin .
Dermatlas Image link
Histologically , the lesion is characterized by proliferation of
atypical melanocytes at all levels in the epidermis. The tumour cells
are present singly and in nests. There is evidence of pagetoid spread in
the epidermis (buckshot spread). The tumour cells may be epithelioid,
spindle or nevus cell-like in appearance. The superficial adnexal
epithelium may be involved.
The differential diagnosis includes
extramammary and mammary Paget's
disease, squamous carcinoma with pagetoid pattern in the epidermis .
S100 and HMB45 stains are positive in melanoma.
Verrucous melanoma is a variant of superficial spreading melanoma and is
characterized by prominent epidermal hyperplasia and elongation of rete
ridges.
Pigmented Bowen's Disease of the
FingerMimicking Malignant Melanoma.
Arch Iran Med. 2007 Apr;10(2):225-7.
Image Link(Dr
Weems)
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