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Classification of Soft Tissue Tumours

Dr Sampurna Roy MD


 

Further reading:

WHO Classification of Soft Tissue Tumours

The evolving classification of soft tissue tumours an update base on 2013 WHO classification

 

Adipocytic Tumours

Benign:

Lipoma 

Lipomatosis 

Lipomatosis of nerve 

Lipoblastoma / Lipoblastomatosis 

Angiolipoma 

Myolipoma 

Chondroid lipoma 

Extrarenal angiomyolipoma 

Extra-adrenal myelolipoma 

Spindle cell/ 

Pleomorphic lipoma 

Hibernoma 

Intermediate (locally aggressive):

Atypical lipomatous tumour/Well differentiated liposarcoma 

Malignant:

Dedifferentiated liposarcoma 

Myxoid liposarcoma 

Round cell  liposarcoma 

Pleomorphic liposarcoma 

Mixed-type liposarcoma 

Liposarcoma, not otherwise specified.

 

Smooth Muscle Tumours

Benign:

Angioleiomyoma

Deep leiomyoma 

Genital leiomyoma

Malignant:

Leiomyosarcoma (excluding skin)

Skeletal Muscle Tumours

Benign:

Rhabdomyoma- adult type ; fetal type ; genital type

Malignant:

Embryonal rhabdomyosarcoma 

(incl. spindle cell, botryoid,anaplastic) 

Alveolar rhabdomyosarcoma (incl. solid, anaplastic) 

Pleomorphic rhabdomyosarcoma


Chondro - Osseous Tumours

Soft tissue chondroma 

Mesenchymal chondrosarcoma 

Extraskeletal osteosarcoma

 

Fibroblastic/ Myofibroblastic Tumours

Benign:

Nodular fasciitis

Proliferative fasciitis

Proliferative myositis

Myositis ossificans

 - fibro-osseous pseudotumour of digits

Ischaemic fasciitis

Elastofibroma 

Fibrous hamartoma of infancy

Myofibroma / Myofibromatosis 

Fibromatosis colli

Juvenile hyaline fibromatosis

Inclusion body fibromatosis

Fibroma of tendon sheath

Desmoplastic fibroblastoma

Mammary-type myofibroblastoma

Calcifying aponeurotic fibroma

Angiomyofibroblastoma 

Cellular angiofibroma 

Nuchal-type fibroma 

Gardner fibroma 

Calcifying fibrous tumour

Giant cell angiofibroma 

Intermediate (locally aggressive)

Superficial fibromatoses (palmar/ plantar)

Desmoid-type fibromatoses 

Lipofibromatosis

Intermediate (rarely metastasizing):

Solitary fibrous tumour  and haemangio- pericytoma 

(incl. lipomatous haemangiopericytoma)

Inflammatory myofibroblastic tumour 

Low-grade myofibroblastic sarcoma 

Myxoinflammatory fibroblastic sarcoma 

Infantile fibrosarcoma 

Malignant:

Adult fibrosarcoma

Myxofibrosarcoma 

Low-grade fibromyxoid sarcoma 

hyalinizing spindle cell tumour

Sclerosing epithelioid fibrosarcoma


So-called Fibrohistiocytic Tumours

Benign:

Giant cell tumour of tendon sheath 

Diffuse-type giant cell tumour 

Deep benign fibrous histiocytoma

Intermediate (rarely metastasizing):

Plexiform fibrohistiocytic tumour 

Giant cell tumour of soft tissues

Malignant:

Pleomorphic ‘MFH’ / Undifferentiated pleomorphic sarcoma 

Giant cell ‘MFH’ / Undifferentiated pleomorphic sarcoma with giant cell

 

 Vascular Tumour

Benign:

Haemangiomas of subcut /deep soft tissue:  capillary ; cavernous ; arteriovenous ; venous ; intramuscular ; synovial.

Epithelioid haemangioma 

Angiomatosis

Lymphangioma 

Intermediate (locally aggressive):

Kaposiform haemangioendothelioma 

Intermediate (rarely metastasizing):

Retiform haemangioendothelioma  

Papillary intralymphatic angioendothelioma 

Composite haemangioendothelioma 

Kaposi sarcoma

Malignant:

Epithelioid haemangioendothelioma 

Angiosarcoma of soft tissue

Pericytic (Perivascular) Tumours:

Glomus tumour (and variants)

Malignant Glomus Tumour 

Myopericytoma 

Tumours of Uncertain Differentiation

Benign:

Intramuscular myxoma (incl. cellular variant)

Juxta-articular myxoma 

Deep (‘aggressive’) angiomyxoma 

Pleomorphic hyalinizing angiectatic tumour

Ectopic hamartomatous thymoma

Intermediate (rarely metastasizing):

Angiomatoid fibrous histiocytoma 

Ossifying fibromyxoid tumour  (incl. atypical / malignant)

Mixed tumour / Myoepithelioma/  Parachordoma

Malignant:

Synovial sarcoma 

Epithelioid sarcoma 

Alveolar soft part sarcoma 

Clear cell sarcoma of soft tissue 

Extraskeletal myxoid chondrosarcoma  ("chordoid" type)

PNET / Extraskeletal Ewing tumour (pPNET)

Extraskeletal Ewing tumour 

Desmoplastic small round cell tumour 

Extra-renal rhabdoid tumour 

Malignant mesenchymoma 

Neoplasms with perivascular epithelioid cell differentiation (PEComa) ;

clear cell myomelanocytic tumour

Intimal sarcoma

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