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Pathology Sebaceous Adenoma

Dr Sampurna Roy MD       


Dermatopathology Quiz Case 2 

Diagnosis: Sebaceous Adenoma




Sebaceous adenoma is a benign sebaceous tumour.

It is closely associated with the Muir-Torre syndrome.

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Sebaceous tumours

Clinical presentation: May be solitary or multiple ;

Yellow-pink circumscribed papule/nodule (0.5 cm in diameter) ;

This may ulcerate or bleed.

Site:  Located on the head and neck region and rarely on the buccal mucosa.

Microscopic features:

Histologically, sebaceous adenoma is a multilobulated tumour sharply demarcated from the surrounding tissue.

Two types of cells are present in the lobules:

The large mature sebaceous cells (sebocytes) are present at the centre.

Smaller, undifferentiated basaloid cells in the periphery.

The cellular lobules contain ductal strutures with holocrine secretion.

Sometimes lobules contain cystic spaces in the centre due to disintegration of mature sebaceous cells.


Cystic sebaceous tumours are regarded as a marker of Muir-Torre syndrome.


Further reading:

Corneal Limbal Sebaceous Adenoma.

Interobserver variability in the diagnosis of circumscribed sebaceous neoplasms of the skin.

A case of sebaceous adenoma of the eyelid showing excessively rapid growth.

Metachronous occurrence of colorectal cancer in a Muir-Torre syndrome patient presenting with recurrent sebaceous adenoma of the eyelid: case report and updated review of the literature.

Clinical, dermoscopic and reflectance confocal microscopy features of sebaceous neoplasms in Muir-Torre syndrome.

Sebaceous adenoma arising within an ovarian mature cystic teratoma in Muir-Torre syndrome.

A rare case of sebaceous adenoma of the palate, with literature review.

Sebaceous adenoma of the submandibular gland: a case report.

Sebaceous adenoma of caruncula lacrimalis: report of two cases.

Immunohistochemical expression of survivin in cutaneous sebaceous lesions.

Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma.

Sebaceous adenoma of the bulbar conjunctiva in association with glioblastoma multiforme and chronic lymphocytic leukemia.

Sebaceous adenomas in an MYH associated polyposis patient of Indian (Gujarati) origin.





Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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