Sebaceous Adenoma

Sebaceous Tumours

http://www.histopathology-india.net/SebTum.htm

HISTOPATHOLOGY-INDIA.NET

Sebaceous Adenoma

Dr Sampurna Roy MD

DermPath-India

Site created by

Dr Sampurna Roy MD

http://www.histopathology-india.net/dermpath.htm

Sebaceous tumours
Fordyce's Spots

Steatocystoma

Nevus Sebaceous

Folliculosebaceous Cystic Hamartoma

Sebaceous Hyperplasia

Sebaceoma

Sebaceous Adenoma

Sebaceous Carcinoma

Benign sweat gland tumours

Cysts:

Hydrocystoma -Eccrine/Apocrine

Hamartomas:

Eccrine/Apocrine naevus

Eccrine Angiomatous Hamartoma

Porokeratotic eccrine ostial naevus

Benign Neoplasms:

Syringocystadenoma Papilliferum

Hidradenoma Papilliferum

Papillary eccrine adenoma

Syringofibroadenoma

Malignant sweat gland tumour

Low grade:

Microcystic adnexal carcinoma

Eccrine epithelioma

Adenoid cystic carcinoma

Mucinous carcinoma

Primary extramammary Paget’s disease

Intermediate grade:

Porocarcinoma

Digital papillary adenocarcinoma

High grade:

Hidradenocarcinoma

Apocrine adenocarcinoma

Eccrine ductal carcinoma

Spiradenocarcinoma

Malignant cylindroma

Outer root sheath differentiation:

Trichilemmoma

Trichilemmal Carcinoma

Proliferating Trichilemmal Cyst (Pilar Tumour)

Matrical differentiation:

Pilomatrixoma and Pilomatrix Carcinoma

Sebaceous adenoma is most closely associated with the Muir-Torre syndrome.

Sebaceous tumours

Clinical presentation: May be solitary or multiple ; Yellow-pink circumscribed papule/nodule ( 0.5 cm in diameter) ; may ulcerate or bleed.

Site: Located on the head and neck region and rarely on the buccal mucosa.

Microscopic features:

Dermatopathology Case Link

Histologically, sebaceous adenoma is a multilobulated tumour sharply demarcated from the surrounding tissue.

Two types of cells are present in the lobules.

The large mature sebaceous cells (sebocytes) are present at the centre.

Smaller, undifferentiated basaloid cells in the periphery

The cellular lobules contain ductal strutures with holocrine secretion.

Sometimes lobules contain cystic spaces in the centre due to disintegration of mature sebaceous cells. Cystic sebaceous tumours are regarded as a marker of Muir-Torre syndrome.

Abstracts

Sebaceous adenoma of oral cavity: report of case and comparative proliferation study with sebaceous gland hyperplasia and Fordyce's granules.Oral Dis. 2003;9(6):323-7.

Sebaceous gland adenoma of the tarsal conjunctiva in a patient with Muir-Torre syndrome.Ophthalmology. 2003 ;110 (9):1833-6.

Frequency of microsatellite instability in unselected sebaceous gland neoplasias and hyperplasias.J Invest Dermatol. 2003;120(5):858-64.

Sebaceous adenoma of the cheek.Oral Oncol. 2002;38(1):111-3.

Sebaceous neoplasms in Muir-Torre syndrome. Am J Dermatopathol. 2000;22(2):155-61

Intra-epidermal and intra-dermal sebocrine adenoma with cystic degeneration and hemorrhage. J Cutan Pathol. 2000 ;27(9):472-5.

Immunohistochemical staining for androgen receptors: a sensitive marker of sebaceous differentiation. Am J Dermatopathol. 1999;21(5):426-31.

Benign sebaceous neoplasm with prominent epidermal component. Am J Dermatopathol. 1998 ;20(2):194-8.