Skin Appendage Tmour

     

http://www.histopathology-india.net/SebTum.htm

               HISTOPATHOLOGY INDIA.COM

                 Microcystic Adnexal Carcinoma

        Dr Sampurna Roy MD

 
Web www.histopathology-india.net
     DermPath-India

      Site created by

  Dr Sampurna Roy MD

          

http://www.histopathology-india.net/dermpath.htm

June 2007
Sebaceous tumours

Fordyce's Spots

Steatocystoma

Nevus Sebaceous

Folliculosebaceous Cystic Hamartoma

Sebaceous Hyperplasia

Sebaceoma

Sebaceous Adenoma

Sebaceous Carcinoma

Benign sweat gland tumours

Cysts:

Hydrocystoma -Eccrine/Apocrine

Hamartomas:

Eccrine/Apocrine naevus

Eccrine Angiomatous Hamartoma

Porokeratotic eccrine ostial naevus

Benign Neoplasms:

Syringocystadenoma Papilliferum

Hidradenoma Papilliferum

Nipple Adenoma

Syringoma

Spiradenoma

Cylindroma

Chondroid Syringoma (benign mixed tumour)

Poroma

Hidradenoma

Apocrine adenoma

Papillary eccrine adenoma

Syringofibroadenoma

Malignant sweat gland tumour 

Low grade:

Microcystic adnexal carcinoma

Eccrine epithelioma

Adenoid cystic carcinoma

Mucinous carcinoma

Primary extramammary Paget’s disease

Intermediate grade:

Porocarcinoma

Digital papillary adenocarcinoma

High grade:

Hidradenocarcinoma

Apocrine adenocarcinoma

Eccrine ductal carcinoma

Spiradenocarcinoma

Malignant cylindroma

                 

Sebaceous adenoma is most closely associated with the Muir-Torre syndrome. Sebaceous tumours

Clinical presentation:  May be solitary or multiple ;  Yellow-pink circumscribed papule/nodule ( 0.5 cm in diameter) ; may ulcerate or bleed.

Site:  Located on the head and neck region. Rarely located on the buccal mucosa.

Microscopic features:

Histologically,  sebaceous adenoma is a multilobulated tumour sharply demarcated from the surrounding tissue.

Two types of cells are present in the lobules.
The large mature sebaceous cells (sebocytes) are present at the centre. Smaller, undifferentiated basaloid cells in the periphery

The cellular lobules contain ductal strutures with holocrine secretion.

Sometimes lobules contain cystic spaces in the centre due to disintegration of mature sebaceous cells. Cystic sebaceous tumours are regarded as a marker of Muir-Torre syndrome.

          
Image Link (Dr Weems)
 

           

 
Web www.histopathology-india.net
Abstracts:

Sebaceous adenoma of oral cavity: report of case and comparative proliferation study with sebaceous gland hyperplasia and Fordyce's granules.Oral Dis. 2003;9(6):323-7.

Sebaceous gland adenoma of the tarsal conjunctiva in a patient with Muir-Torre syndrome.Ophthalmology. 2003 ;110 (9):1833-6.

Frequency of microsatellite instability in unselected sebaceous gland neoplasias and hyperplasias.J Invest Dermatol. 2003;120(5):858-64.

Sebaceous adenoma of the cheek.Oral Oncol. 2002;38(1):111-3.

Sebaceous neoplasms in Muir-Torre syndrome. Am J Dermatopathol. 2000;22(2):155-61

Intra-epidermal and intra-dermal sebocrine adenoma with cystic degeneration and hemorrhage. J Cutan Pathol. 2000 ;27(9):472-5.

Immunohistochemical staining for androgen receptors: a sensitive marker of sebaceous differentiation. Am J Dermatopathol. 1999;21(5):426-31.

Benign sebaceous neoplasm with prominent epidermal component. Am J Dermatopathol. 1998 ;20(2):194-8.

Your Banner

Soft Tissue Pathology;

Myxoid Tumours of Soft Tissue Classification of Soft Tissue Tumour;  Gross examination of soft tissue specimen ;  A practical approach to histopathological reporting of soft tissue tumours Grading of soft tissue tumours ; Lipomatous tumours ;Neural tumours ; Myogenic tumours ; Fibroblastic/Myofibroblastic tumours ; Myofibroblastic tumours ;  Fibrohistiocytic tumours ; ChondroOsseous tumours ; Soft TissueTumours of Uncertain Differentiation ; Notochordal Tumour -Chordoma ;Extra-adrenal Paraganglioma ; Gastrointestinal Stromal Tumour ;

Surgical-Pathology.com

Histopathology-India.net

Eye Pathology Online

Cardiac Path Online;

Pulmonary Pathology Online

Pathology Quiz Online;

Dermpath-India;

GI Path Online

Mesothelioma-Online;

Soft Tissue Pathology;

Case Index

Infectious Disease Online; INDEX: A-D ; INDEX: E-L ; INDEX: M-P INDEX: Q-Z ; FUNGAL DISEASE ; VIRAL DISEASE.

Tumours of the Hair Follicle

Hair Germ Differentiation:

Trichoepithelioma 

Desmoplastic Trichoepithelioma

Trichofolliculoma

Trichoblastoma

Cutaneous lymphadenoma

                          
    
Infundibular differentiation:

Trichoadenoma

Dilated Pore of Winer

Pilar Sheath Acanthoma

Tumour of Follicular Infundibulum

Outer root sheath differentiation:
                    
Trichilemmoma

Trichilemmal Carcinoma

Proliferating Trichilemmal Cyst (Pilar Tumour)

Matrical differentiation:
                  
Pilomatrixoma and Pilomatrix Carcinoma