Dermpath-India

Pathology Sebaceous Adenoma

Dr Sampurna Roy MD              2022

It is closely associated with the Muir-Torre syndrome.

Clinical presentation: May be solitary or multiple ;

Yellow-pink circumscribed papule/nodule (0.5 cm in diameter) ;

This may ulcerate or bleed.

Site:  Located on the head and neck region and rarely on the buccal mucosa.

Microscopic features:

Histologically, sebaceous adenoma is a multilobulated tumour sharply demarcated from the surrounding tissue.

Two types of cells are present in the lobules:

The large mature sebaceous cells (sebocytes) are present at the centre.

Smaller, undifferentiated basaloid cells in the periphery.

The cellular lobules contain ductal strutures with holocrine secretion.

Sometimes lobules contain cystic spaces in the centre due to disintegration of mature sebaceous cells.

Dermatopathology Quiz Case

 

Cystic sebaceous tumours are regarded as a marker of Muir-Torre syndrome.