Pathology of Sinonasal Hemangiopericytoma
hemangiopericytoma is a rare upper aerodigestive tract tumour of unknown
The most frequent site of occurence is the nasal cavity and paranasal
The tumour is composed of uniform, spindle shaped cells with round to oval nuclei arranged in short fascicles.
The vascular component includes capillary size to large sinusoidal spaces.
Some vessels have a staghorn like appearance.
Perivascular hyalinization is often
I) Soft tissue type hemangiopericytoma:
Locally destructive and may metastasize to regional lymphnode and lung ;
Do not show myoid differentiation ;
Smooth muscle actin and other myoid markers are negative;
Very recently intimate relationships between hemangiopericytoma and solitary fibrous tumor have been reported.
It is important to differentiate these tumours, because most solitary fibrous tumors of the soft tissue are benign.
II) True hemangiopericytoma:
Benign behaviour ;
Do not metastasize ;
Tumour has a myogenic appearance and shows convincing pericytic differentiation ;
Smooth muscle actin is positive ;
Some of these tumours recur locally.
III) Sinonasal glomus tumours: Striking pathology gold: a singular experience with daily reverberations: sinonasal hemangiopericytoma (glomangiopericytoma) and oncogenic osteomalacia.Head Neck Pathol. 2012 Mar;6(1):64-74
Histology ranges from a typical glomus tumour composed of compact epithelioid cells to tumours indistinguishable from perivascular myoma.
Glomus and glomus-like tumours and true hemangiopericytomas are likely to belong to one cellular spectrum.
Differential Diagnosis of Sinonasal Hemangiopericytoma: Sinonasal true hemangiopericytoma should be differentiated from soft tissue- type hemangiopericytoma because of its far better prognosis.
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