Granulomatous Reaction Pattern of the Skin

Site created by

Dr Sampurna Roy MD

http://www.histopathology-india.net/dermpath.htm

Microcystic Adnexal Carcinoma

Dr Sampurna Roy MD

Enter your search terms Submit search form

Web www.histopathology-india.net

www.surgical-pathology.com www.pathology-india.com

Click on the image

May 2009

A granulomatous reaction pattern is defined as a dermal chronic inflammatory pattern in which granulomas are present.

Granulomas are organised well formed discrete collection of histiocytes or epithelioid cells together with variable numbers of multinucleated giant cells and other inflammatory cells.

CLASSIFICATION:

1.SARCOIDAL:

Granulomas ('naked' granulomas) are composed of epithelioid histiocytes and multinucleated giant cells with only sparse infiltrate of lymphocytes and plasma cells at the periphery.

Sarcoidosis
Reaction to foreign material ; CLICK

2. TUBERCULOID:

Confluent granulomas composed of epithelioid histiocytes, giant cells (Langhans and foreign body type), and prominent mononuclear infiltrate (lymphocytes and plasma cells) surrounding the granuloma.

Tuberculosis; Image
Leprosy ; Image
Late Syphilis ; Image
Leishmaniasis ; Path Quiz 52 ; Image.
Rosacea;
Crohn's disease; Image

3. SUPPURATIVE:

Granulomas are composed of epithelioid cells, with or without multinucleated giant cells, central collections of neutrophils and chronic inflammatory cells in the periphery.

Chromomycosis/phaeohypomycosis ; Image
Sporotrichosis;
Mycobacterium marinum infection ; Image
Coccidiomycosis
Paracoccidioidomycosis
Mycetoma , Nocardiosis , Actinomycosis;
Cat Scratch Disease;
Blastomycosis-like pyoderma;

4. NECROBIOTIC:

Granuloma annulare;
Necrobiosis lipoidica ; Path Quiz 55
Rheumatoid nodule ; Path Quiz 53
Pseudorheumatoid nodule (deep granuloma annulare) ; Path Quiz 54
Necrobiotic xanthogranuloma;

5. FOREIGN BODY TYPE:

Foreign body type granulomas are characterized by identifiable foreign material together with epithelioid cells, multinucleated foreign body giant cells and inflammatory cells.
Exogenous material
Endogenous material

6. MISCELLANEOUS GRANULOMAS:

Melkersson-Rosenthal syndrome Annular Elastolytic Giant Cell Granuloma
Interstitial Granulomatous Dermatitis
Interstitial Granulomatous Drug Reaction
Granulomatous T-cell lymphoma

Foreign body-type granuloma(Dr Weems)

Granuloma annulare (Dr Weems)Image1 ; Image2

Perforating Granuloma Annulare(Dr Weems)Image

Visit: Infectious Granuloma of the Lung ; Pathological Diagnosis of Granulomatous Lung Diseases ; Non-necrotising Granulomatous Inflammation of the lung ; An approach to Histopathological examination of Pulmonary Granulomatous Inflammation ;