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Granulomatous Reaction

Pattern of the Skin                    

Dr Sampurna Roy MD


Infectious Disease Online

 Site created by

 Dr Sampurna Roy MD

          

http://www.histopathology-india.net/Infection.htm

February 2014
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Normal Histology of Skin

Glossary

Gross examination of the skin specimen

Reporting of biopsies taken for Inflammatory Skin Diseases

Lichenoid (Interface)Tissue Reaction Pattern

Psoriasiform Reaction Pattern

Granulomatous Reaction Pattern

Vesiculobullous Reaction Pattern

Spongiform Reaction Pattern

Vascular Diseases: Various forms of Vasculitis

Lichen planus-like  lesions

Lichen Nitidus

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Hailey-Hailey Disease 

Cutaneous Deposits

Calcinosis Cutis

Gout

Silicone granulomas

Granulomatous Reaction Pattern of the Skin

Granuloma Annulare

Necrobiosis Lipoidica

Necrobiotic Xanthogranuloma   

Rheumatoid Nodule

Lupus Vulgaris

Cutaneous  Sarcoidosis

Melkersson Rosenthal Syndrome

Annular Elastolytic Giant Cell Granuloma

Skin lesion in Crohn's Disease

Blastomycosis-like pyoderma

Rosacea

Interstitial Granulomatous Dermatitis

Interstitial Granulomatous Drug Reaction

Granulomatous T-cell lymphoma

Erythema Nodosum

Folliculitis

Impetigo

Furuncle(Boil)

Carbuncle

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Cutaneous lesion in graft-versus host disease

Cutaneous lesions after exposure to Radiation

Role of immuno histochemistry in Dermatopathology 

Cutaneous Pseudolymphoma

Cutaneous infection and infestations

Cutaneous infection and infestations

Histopathological patterns in cutaneous  infections

Cutaneous lesion associated
with AIDS

Mucinous carcinoma

Extramammary Paget's disease

Digital papillary adenocarcinoma

Microcystic adnexal carcinoma

                                 
A granulomatous reaction pattern is defined as a dermal chronic inflammatory pattern in which granulomas are present.

Granulomas are organised well formed discrete collection of histiocytes or epithelioid cells together with variable numbers of multinucleated giant cells and other inflammatory cells.

Classification: 

1.Sarcoidal

 

Granulomas ('naked' granulomas) are composed of epithelioid histiocytes and multinucleated giant cells with only sparse infiltrate of lymphocytes and plasma cells at the periphery.

Cutaneous Sarcoidosis

Reaction to foreign material

 

2. Tuberculoid

 

Confluent granulomas composed of epithelioid histiocytes, giant cells (Langhans and foreign body type), and prominent mononuclear infiltrate (lymphocytes and plasma cells) surrounding the granuloma.

Tuberculosis (Lupus Vulgaris Image

Leprosy ; Image

Late Syphilis Image

Leishmaniasis  ; Path Quiz 52  ; Image.

Rosacea ;

Crohn's disease; Image

 

3. Suppurative

 

Granulomas are composed of epithelioid cells, with or without multinucleated giant cells, central collections of neutrophils and chronic inflammatory cells in the periphery.

Chromomycosis/phaeohypomycosis ; Image

Sporotrichosis;

Mycobacterium marinum infection ;

Coccidiomycosis;

Paracoccidioidomycosis;

Mycetoma ;

Nocardiosis ;

Actinomycosis;

Cat Scratch Disease;

Blastomycosis-like pyoderma;

 

4. Necrobiotic 

 

Granuloma annulare;

Necrobiosis lipoidica ; Path Quiz 55

Rheumatoid nodule Path Quiz 53

Pseudorheumatoid nodule (deep granuloma annulare) ; Path Quiz 54

Necrobiotic xanthogranuloma;

 

5. Foreign Body Type

 

Foreign body type granulomas are characterized by identifiable foreign material together with epithelioid cells, multinucleated foreign body giant cells and inflammatory cells.

Exogenous material

Endogenous material

 

6. Misellaneous Granulomas

Melkersson Rosenthal Syndrome

Annular Elastolytic Giant Cell Granuloma            

Interstitial Granulomatous Dermatitis

Interstitial Granulomatous Drug Reaction

Granulomatous T-cell lymphoma

 

                               

Abstract:

Crohn's disease: an important differential diagnosis of granulomatous skin diseases.

A Case of Foreign-Body Granuloma of the Glabella due to Polyacrylamide Filler and an Intractable Ulcer after Skin Biopsy: An Immunohistochemical Evaluation of Inflammatory Changes.

Fish tank granuloma caused by Mycobacterium marinum.

Expression of Notch Signaling Components in Cutaneous Foreign Body and Sarcoidal Granulomas and Fusing Macrophages.

Granulomatous skin lesions, severe scrotal and lower limb edema due to mycobacterial infections in a child with complete IFN-γ receptor-1 deficiency.

Cutaneous leishmaniasis with histopathologic pattern of non-necrotizing granulomatous dermatitis in patients treated with adalimumab.

Chromoblastomycosis in Kerala, India.

Histopathological spectrum of cutaneous tuberculosis and non-tuberculous mycobacterial infections.

Related Links:

Granulomatous lesions ( Dr Yale Cohen)

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