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Small Cell Carcinoma of the Lung |
Path Quiz Case-82: Diagnosis-
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An
outline of the anatomy and normal histology of the stomach for
pathologists. Reporting of gastric biopsies (non-neoplastic gastric lesions). Pathology and pathogenesis of peptic ulcer. Reactive /Reflux/ Chemical Gastritis (Type C) Other Non-Neoplastic Gastric Lesions |
Age: Middle aged or elderly male (mostly in sixth decade of life).
Clinical presentation: Dysphagia, weight loss. Poor prognosis. Associated with widespread metastasis. Often there is a history of heavy smoking.
Macroscopic features: Present in mid and lower esophagus as a large exophytic, polypoid mass or stenotic lesion. The lesion may vary in size from 5-15cm in greatest diameter.
Microscopic feature:
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The tumour is characterized by small, round or oval lymphocyte-like cells with hyperchromatic nuclei, scant cytoplasm, and frequent mitoses.
In some cases in-situ lesions are present in the adjacent squamous epithelium.
Foci of squamous carcinoma, adenocarcinoma, or both, may be present. There may be mature-appearing balls of squamous cells.
General features include:
Small
anaplastic cells ; Moulded nuclei ; Arranged in sheets (sometimes in cords and ribbons) ;
Rosettes formation containing mucin within their lumens in some case ; Foci of necrosis ; Vascular invasion
; Lymphnode metastases.
Special stains:
Immunohistochemistry-
The tumour stains positively with
Chromogranin, PGP9.5, synaptophysin (endocrine
markers).
Histochemistry-
The argyrophilic granules are demonstrated by
the silver stain
(Grimelius) .
Differential diagnosis: Metastatic oat cell carcinoma from primary lung tumour ; Poorly differentiated squamous cell carcinoma ; Basaloid squamous cell carcinoma ; Lymphoma
Note: Squamous cell carcinomas shows a general gradation of smaller to larger squamous cells with intercellular bridges. Keratinization may be present.
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Abstracts: Primary undifferentiated small cell carcinoma of the esophagus.Hum Pathol. 1999 Feb;30(2):216-21. Primary small cell carcinoma of the esophagus.Acta Gastroenterol Latinoam. 1995;25(3):171-5. Small cell carcinoma of the oesophagus: a clinical and immunohistopathological review.Eur J Surg Oncol. 1990 Apr;16(2):109-15. Small cell carcinoma of the esophagus.Cancer. 1989 Feb 1;63(3):564-73. Oat cell carcinoma of the esophagus.J Surg Oncol. 1982 Mar;19(3):145-50 Oat cell carcinoma of the esophagus.Cancer. 1980 May 1;45(9):2342-7.
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NORMAL HISTOLOGY OF ESOPHAGUS AN APPROACH TO THE REPORTING OF ESOPHAGEAL BIOPSIES BARRETT'S ESOPHAGUS (INTESTINAL METAPLASIA DYSPLASIA & ADENOCARCINOMA) BENIGN TUMOURS AND TUMOUR - LIKE CONDITIONS OF ESOPHAGUS 1. SQUAMOUS PAPILLOMA OF THE ESOPHAGUS 2. INFLAMMATORY FIBROID POLYP OF THE ESOPHAGUS 4. GRANULAR CELL TUMOUR OF THE ESOPHAGUS REPORTING OF ESOPHAGEAL RESECTION SPECIMENS SQUAMOUS EPITHELIAL DYSPLASIA INCLUDING SQUAMOUS CELL CARCINOMA IN-SITU OF THE ESOPHAGUS |
Normal histology of the small intestine for anatomic pathologists An approach to evaluation of small intestinal biopsy. Malabsorption syndrome (causes and clinical investigations) Enteropathy-associated T-cell lymphoma
Lesions causing small bowel
obstruction and bleeding - |
| Pathogens commonly affecting Small Intestine |
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Enterobiasis
Epstein-Barr Virus Related Malignant Tumours |
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Neuroendocrine Tumours of the Lung;
Normal Neuroendocrine Cells of the Lung; Diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH); |