http://www.histopathology-india.net/EsophagealPathology.htm

Age-   Occurs in middle aged male.

Clinical presentation- Dysphagia and weight loss.

Macroscopic features - Present in mid & lower esophagus . Bulky, polypoid, intraluminal tumour.

Microscopic features- Characterized by:
- Biphasic histologic pattern.  

i) Malignant spindle cells
ii) In-situ or invasive squamous cell carcinoma (occasionally adenocarcinoma)

- The malignant spindle cells (predominant component) arranged in interlacing fascicles.
-Numerous mitotic figures and bizarre giant cells 
-Malignat heterologous elements  (bone, cartilage, striated muscle).
- The tumour infiltration is usually superficial (accounts for better prognosis).
- The metastatic tumour may contain one or both components.

Immunohistochemistry-
Spindle cells may be positive with cytokeratin.  Smooth muscle  and neural markers are usually negative.

Differential diagnosis-
- Polypoid leiomyosarcoma - multiple deeper blocks are necessary to demonstrate in-situ or invasive carcinoma. Immunohistochemistry is also useful in establishing the diagnosis.
- Granulation tissue with bizarre stromal cells.

Visit: Biphasic Epithelial/Mesenchymal Lung Tumours ; Pulmonary Carcinosarcoma ; Pulmonary Blastoma ; Leiomyosarcoma of the Soft Tissue ;

Abstracts:

True carcinosarcoma of the esophagus.Dis Esophagus. 2006;19(1):48-52.

Esophageal carcinosarcoma with basaloid squamous carcinoma and rhabdomyosarcoma components with TP53 mutation.Pathol Int. 2004 ;54(10): 803-9.

Carcinosarcoma of the esophagus characterized by myoepithelial and ductal differentiations.Pathol Int. 2002 Oct;52(10):657-63.

Esophageal carcinosarcoma.J Gastrointest Surg. 2001 Jul-Aug;5(4):414-7.

Carcinosarcoma of the esophagus--pattern of recurrence.Dig Surg. 2001;18(3):216-8.

Rapid-growing carcinosarcoma of the esophagus arising from intraepithelial squamous cell carcinoma: report of a case.Surg Today. 2000;30(2):173-6.

Clinicopathological studies of esophageal carcinosarcoma: analyses of its morphological characteristics using endoscopic, histological, and immunohistochemical procedures.Endoscopy. 2000 Sep;32(9):706-11.

Carcinosarcoma of the esophagus with metastases showing osteosarcoma: a case report and review of the literature.Dis Esophagus. 1998 Jul;11(3):189-93.

p53 immunoreactivity in carcinosarcoma of the esophagus.J Surg Oncol. 1994 Jun;56(2):132-5.

Polypoid adenosquamous carcinoma of the esophagus with prominent spindle cells. Report of a case with immunohistochemical and ultrastructural studies.Arch Pathol Lab Med. 1993 May;117(5):544-7.

Polypoid squamous cell carcinoma of the esophagus.Cancer. 1989 Jul 1;64(1): 94-7.

Polypoid tumor of the esophagus.Hum Pathol. 1987 Jul;18(7):692-700.

Esophageal carcinoma with prominent spindle cells.Cancer. 1987;60(9):2244-50.

Carcinosarcoma of the esophagus. An immunohistochemical and electron microscopic study.Acta Pathol Jpn. 1986 Jan;36(1):151-9.

Clinical and pathological characteristics of carcinosarcoma of the esophagus: report of four cases.Ann Thorac Surg. 1984 Mar;37(3):197-203.

Polypoid squamous carcinoma of the esophagus. A case report with immuno staining for keratin.Am J Surg Pathol. 1983;7(5):495-9.

Carcinoma of the oesophagus with spindle cell features.Histopathology. 1981 ;5(4):403-14.

Polypoid carcinoma of the esophagus. A unifying term for "carcinosarcoma" and "pseudosarcoma".Am J Surg Pathol. 1978  Jun;2(2):201-8.

AN APPROACH TO THE  REPORTING  OF ESOPHAGEAL BIOPSIES

BARRETT'S   ESOPHAGUS   (INTESTINAL METAPLASIA  DYSPLASIA  &   ADENOCARCINOMA)

BENIGN TUMOURS AND  TUMOUR - LIKE CONDITIONS  OF  ESOPHAGUS

 1. SQUAMOUS PAPILLOMA OF THE ESOPHAGUS

 2. INFLAMMATORY FIBROID POLYP OF THE ESOPHAGUS

 3. LEIOMYOMA OF THE ESOPHAGUS

 4. GRANULAR CELL TUMOUR OF THE ESOPHAGUS

 5. ESOPHAGEAL CYSTS

 6. GLYCOGENIC ACANTHOSIS

 7.FIBROVASCULAR POLYPS

REPORTING  OF  ESOPHAGEAL  RESECTION SPECIMENS

SQUAMOUS  EPITHELIAL  DYSPLASIA INCLUDING SQUAMOUS CELL CARCINOMA IN-SITU OF THE ESOPHAGUS

SMALL CELL CARCINOMA OF THE ESOPHAGUS

DRUG  RELATED  LESIONS  OF  THE GASTROINTESTINAL TRACT

Normal histology of the small intestine 

An approach to evaluation of small intestinal biopsy.

Tropical Sprue

Coeliac Disease

Enteropathy-associated T-cell lymphoma

Intestinal lymphangiectasia

Brunner's Gland Adenoma

Duodenal  Gangliocytic Paraganglioma

Lymphoma of the small intestine