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Pulmonary Pathology Online

Exfoliative Pulmonary Cytology - Features of Squamous Cell Carcinoma

Dr Sampurna Roy MD

 

                                                                                                                      

 

 

Image1: Sputum-  Malignant keratinized squamous cells.

Image2: Sputum- Malignant Squamous cells of variable shape and size together with nuclear pleomorphism.

 

1. A common, centrally placed endobronchial tumor with surface necrosis, therefore easily sampled with plentiful abnormality.

2. Dissociated malignant squamous cells should be present for diagnosis.

3. Well differentiated tumors yield pleomorphic cells including fibre and tadpole cells with densely keratinized cytoplasm and pyknotic or hyperchromatic irregular nuclei.

4. Non keratinizing carcinoma cells occur in sheets with vesicular nuclei,visible nucleoli, isolated keratinizing cells may be seen.

5. Necrosis is frequently present and may include multinucleated giant cells in keratinized debris.

 

Further reading:

Induced sputum in the diagnosis of peripheral lung cancer not visible endoscopically.

Cytomorphologic changes in split-course radiation-treated bronchogenic carcinomas.

Cytologic features of peripheral squamous cell carcinoma of the lung.

Value of sputum cytology in the diagnosis and typing of bronchogenic carcinomas, excluding adenocarcinomas.

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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