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Squamous Epithelial Dysplasia

including Squamous Cell

Carcinoma in-situ

of the Esophagus

   Dr Sampurna Roy MD

GI Path Online- Home Page  Esophageal Pathology- Home Page    

August 2015


Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


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Invasive esophageal squamous cell carcinoma evolves through a series of preinvasive lesions, known as dysplasias or intraepithelial neoplasias.

Esophagus has its own unique types which may differ from those occurring in other squamous sites, such as cervix and skin.

According to some studies these precursor lesions were more common in high cancer-risk areas than in the low-risk areas.

There is an increased proliferation of cells in the upper layers of the esophageal squamous epithelium in people who live in these areas.

Although lower grades of dysplasia are usually described as partial-thickness abnormalities, involving less than half of the epithelial thickness and higher grades as involving more than half, separating grades of dysplasia on the basis of level of involvement is not always reliable.

Also, separating one grade of dysplasia from another is frequently difficult, since there are no clear lines of demarcation.

As a result, even with a two-grade system that includes low and high grades, there are occasional dysplasias that seem to be borderline or intermediate between the two grades.

In the future, all intraepithelial proliferations might be grouped into a spectrum that could be designated esophageal intraepithelial neoplasia (EIN), comparable to the terms in use for the uterine cervix, the vagina, and the vulva, or into a two-grade dysplasia system comparable to that used in ulcerative colitis.

The lesion is visible endoscopically and is confirmed histologically

Microscopic features : 

The preinvasive lesions, or dysplasias, contain abnormal epithelia which vary from that closely resembling the normal squamous mucosa to epithelium so disorganized that its malignant cytologic and architectural features are obvious.

There are atypical squamous cells with disorganized architecture and abnormal differentiation within the epithelium.

These features are obvious in high grade dysplasia.

The nuclei are larger and more hyperchromatic than normal,and there is increased mitotic activity.

The lower grades of dysplasia have a larger component of mature-appearing squamous cells, some of which may be keratinized, and the abnormal cells are often limited to the lower half of the epithelium .

The highest grade of dysplasia is squamous cell carcinoma in situ or intraepithelial carcinoma.

The histological variants:

1.Basal squamous dysplasia  2.Pagetoid squamous dysplasia   

The lesion may  present as a single lesion in the absence of invasive tumour or as a peripheral component in the backround squamous mucosa , with invasive squamous carcinoma.


Further reading:

Effects of endoscopic mucosal resection in patients with low-grade intraepithelial dysplasia of esophageal squamous cells.

High-grade dysplasia, restricted to the basal cell layer involving the entire esophagus.

Toll-like receptor 9 is a novel biomarker for esophageal squamous cell dysplasia and squamous cell carcinoma progression.

Predicting the risk of squamous dysplasia and esophageal squamous cell carcinoma using minimum classification error method.

Risk factors for oesophageal squamous dysplasia in adult inhabitants of a high risk region of China.

Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran.

Esophageal papillomatosis complicated by squamous cell carcinoma in situ.

Squamous esophageal histology and subsequent risk of squamous cell carcinoma of the esophagus. A prospective follow-up study from Linxian, China. 

Histological classification of intraepithelial neoplasias and microinvasive squamous carcinoma of the esophagus.

Esophageal squamous dysplasia.


  GI Path Online- Home Page Esophageal Pathology- Home Page    

Normal Histology of Esophagus

An approach to the reporting of esophageal biopsies

Barrett's Esophagus (Intestinal metaplasia, dysplasia and adenocarinoma )

Benign tumours and tumour -like conditions of esophagus.

 1. Squamous papilloma of the esophagus

 2.Inflammatory fibroid polyp of the esophagus

 3. Leiomyoma of the esophagus

 4. Granular cell tumour of the esophagus

 5. Esophageal cysts 

 6. Glycogenic acanthosis 

Reporting of esophageal resection specimens

Squamous epithelial dysplasia  including squamous cell carcinoma in-situ of the esophagus

Small cell carcinoma of the esophagus 

Drug related lesions of the gastrointestinal tract.


An outline of the  anatomy and normal histology of the  stomach for pathologists.

Reporting of gastric biopsies (non- neoplastic gastric lesions).

Pathology and pathogenesis of peptic ulcer.

Acute Gastritis 

Chronic Gastritis

Helicobacter pylori  associated (TypeB)  Gastritis 

Autoimmune Gastritis (Type A) 

Reactive /Reflux/ Chemical Gastritis (Type C)

Lymphocytic Gastritis

Collagenous Gastritis

Granulomatous Gastritis

Eosinophilic Gastritis

Gastric Carcinoid Tumour



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