Gastrointestinal Stromal Tumour

www.histopathology-india.net/GIPath.htm

 SMALL INTESTINE

 LARGE INTESTINE

                                    HISTOPATHOLOGY INDIA.COM

                    Atypical Fibroxanthoma

    Dr Sampurna Roy MD

 
Web www.histopathology-india.net
April 2007
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An outline of the anatomy and normal histology of the  stomach for pathologists.

Reporting of gastric biopsies (non-neoplastic gastric lesions).

Pathology and pathogenesis of peptic ulcer.

Acute Gastritis 

Chronic Gastritis

Helicobacter pylori  associated(TypeB) Gastritis 

Autoimmune Gastritis (Type A) 

Reactive /Reflux/ Chemical Gastritis (Type C)

Lymphocytic Gastritis

Collagenous Gastritis

Granulomatous Gastritis

Eosinophilic Gastritis

Gastric Xanthoma/Xanthelasma

Other Non-Neoplastic Gastric Lesions

Benign tumour and tumour- like lesions

Gastric Lymphoma

Gastric Carcinoid Tumour

Gastrointestinal Stromal Tumour 

Gastric Epithelial Dysplasia

Early Gastric Carcinoma

Gross Examination of the Gastrectomy Specimen 

Drug related lesions of the gastrointestinal tract

- Normal Histology of the Large Intestine

- Interpretation of Large Intestinal Biopsies

- Assessment of abnormalities -1 (lumen, surface epithelium, subepithelial zone)

- Assessment of abnormalities - 2  (crypt density , architecture and epithelium)

- Assessment of abnormalities - 3 (changes in the lamina propria,muscularis mucosae and submucosa) 

         
The squamous papilloma of the esophagus is a rare disease. The pathogenesis and biological features of the disorder are not clearly known.  Markers of human papilloma virus infection have been found in some cases. Role of the virus in the pathogenesis of the tumor is not known. Some authors have suggested an association with GERD others support  the hypothesis that mucosal injury and regeneration underlies the etiology of esophageal squamous cell papilloma formation.

Site-  Lower third of the esophagus

Gross- Usually less than 1.5 cm in maximum diameter. Single, sessile, well circumscribed, intraluminal nodule. In about 10% of cases, the tumors are multiple .

Microscopic feature-
Papillary  lesion lined by hyperplastic squamous epithelium with a fibrovascular connective tissue core.
Koilocytosis and multinucleation may be present indicating viral origin.

The risk for malignant change of squamous cell papillomas appears to be extremely low.

Differential diagnosis:  Verrucous carcinoma of esophagus.

   Visit: Epidermal tumours

         

 
Web www.histopathology-india.net

Abstracts:

Squamous papilloma of the esophagus. Clinical and pathological observations based on 172 papillomas in 155 patients.Orv Hetil. 2005 Mar 20;146(12):547-52.

Regression of esophageal papillomatous polyposis caused by high-risk type human papilloma virus.J Gastroenterol. 2003;38(6):579-83.

Squamous papilloma of the esophagus: long-term follow up.J Gastroenterol Hepatol. 2001 Aug;16(8):857-61.

Squamous cell papillomatosis of esophagus following placement of a self-expanding metal stent.Dig Dis Sci. 1999 Mar;44(3):457-61.

p53 protein expression in esophageal squamous cell papillomas: a study of 36 lesions.Scand J Gastroenterol. 1996 Jan;31(1):10-3.

Papillomatosis of the esophagus.J Clin Gastroenterol. 1996 Jan;22(1):35-7.

Papillomavirus in esophageal papillomas and carcinomas. Int J Cancer. 1999 Mar 1;80(5):681-4.

Squamous papilloma of the esophagus.Zhonghua Yi Xue Za Zhi (Taipei). 1996 Jun;57(6):413-7.

Squamous esophageal papillomas.Ned Tijdschr Geneeskd. 1996 May 4;140(18):987-90.

Squamous papilloma of the esophagus: report of six cases with long-term follow-up in four patients.Am J Gastroenterol. 1986 Nov;81(11):1059-62.

Soft Tissue Pathology;

Myxoid Tumours of Soft Tissue Classification of Soft Tissue Tumour;  Gross examination of soft tissue specimen ;  A practical approach to histopathological reporting of soft tissue tumours Grading of soft tissue tumours ; Lipomatous tumours ;Neural tumours ; Myogenic tumours ;Vascular tumours ;Fibroblastic/Myofibroblastic tumours ; Myofibroblastic tumours ;  Fibrohistiocytic tumours ; ChondroOsseous tumours ; Soft TissueTumours of Uncertain Differentiation ; Notochordal Tumour -Chordoma ;Extra-adrenal Paraganglioma ; Gastrointestinal Stromal Tumour

      
NORMAL HISTOLOGY OF ESOPHAGUS

AN APPROACH TO THE  REPORTING  OF ESOPHAGEAL BIOPSIES

BARRETT'S   ESOPHAGUS   (INTESTINAL METAPLASIA  DYSPLASIA  &   ADENOCARCINOMA)

BENIGN TUMOURS AND  TUMOUR - LIKE CONDITIONS  OF  ESOPHAGUS

 1. SQUAMOUS PAPILLOMA OF THE ESOPHAGUS

 2. INFLAMMATORY FIBROID POLYP OF THE ESOPHAGUS

 3. LEIOMYOMA OF THE ESOPHAGUS

 4. GRANULAR CELL TUMOUR OF THE ESOPHAGUS

 5. ESOPHAGEAL CYSTS

 6. GLYCOGENIC ACANTHOSIS

 7.FIBROVASCULAR POLYPS

REPORTING  OF  ESOPHAGEAL  RESECTION SPECIMENS

SQUAMOUS  EPITHELIAL  DYSPLASIA INCLUDING SQUAMOUS CELL CARCINOMA IN-SITU OF THE ESOPHAGUS

SMALL CELL CARCINOMA OF THE ESOPHAGUS

DRUG  RELATED  LESIONS  OF  THE GASTROINTESTINAL TRACT

 

Pathogens commonly affecting Small Intestine

Ascariasis

Cryptosporidium

Cytomegalovirus infection

Giardiasis

Hookworm Infection

Isosporiasis

Microsporidia

Mycobacterium Avium Intracellulare

Schistosomiasis

Whipple's disease