| The
squamous papilloma of the esophagus is a rare disease. The pathogenesis and
biological features of the disorder are not clearly known.
Markers of
human papilloma virus infection have been found in some cases. Role of
the virus in the pathogenesis of the tumor is not known. Some authors
have suggested an association with GERD others support
the hypothesis that mucosal injury and regeneration underlies the
etiology of esophageal squamous cell papilloma formation.
Site-
Lower third of the esophagus
Gross-
Usually less than 1.5 cm in maximum diameter. Single, sessile,
well circumscribed, intraluminal nodule.
In about 10% of cases, the tumors
are multiple .
Microscopic feature-
Papillary lesion lined by hyperplastic squamous epithelium with a
fibrovascular connective tissue core.
Koilocytosis and multinucleation may be present indicating viral
origin.
The risk
for malignant change of squamous cell papillomas appears to be
extremely low.
Differential diagnosis:
Verrucous carcinoma of esophagus.
Visit:
Epidermal tumours
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