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Pathology of Squamous

Papilloma of the Esophagus

Dr Sampurna Roy MD



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The squamous papilloma of the esophagus is a rare disease.

The pathogenesis and biological features of the disorder are not clearly known.

Markers of human papilloma virus infection have been found in some cases. Role of the virus in the pathogenesis of the tumor is not known.

Some authors have suggested an association with GERD others support  the hypothesis that mucosal injury and regeneration underlies the etiology of esophageal squamous cell papilloma formation.

Site-  Lower third of the esophagus

Gross- Usually less than 1.5 cm in maximum diameter. Single, sessile, well circumscribed, intraluminal nodule. In about 10% of cases, the tumors are multiple .

Microscopic feature-

Papillary lesion lined by hyperplastic squamous epithelium with a fibrovascular connective tissue core.

Koilocytosis and multinucleation may be present indicating viral origin.

The risk for malignant change of squamous cell papillomas appears to be extremely low.

Differential diagnosis:  Verrucous carcinoma of esophagus.

Further reading:

Squamous papilloma of the esophagus. Clinical and pathological observations based on 172 papillomas in 155 patients.

Regression of esophageal papillomatous polyposis caused by high-risk type human papilloma virus.

Squamous papilloma of the esophagus: long-term follow up.

Squamous cell papillomatosis of esophagus following placement of a self-expanding metal stent.

p53 protein expression in esophageal squamous cell papillomas: a study of 36 lesions.

Papillomatosis of the esophagus.

Papillomavirus in esophageal papillomas and carcinomas.  

Squamous papilloma of the esophagus.

Squamous esophageal papillomas.

Squamous papilloma of the esophagus: report of six cases with long-term follow-up in four patients.



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Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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