The gastric mucosa consists of surface
epithelium, gastric pits and gastric glands.
The gastric glands extend from the
muscular mucosae to extend into the stomach lumen via gastric pits.
The foveolar cells lining the surface and
gastric pits are identical throughout the stomach
Glands differ in different regions of the stomach.
Gastric pits occupy approximately 25% of the mucosa. Pits lie parallel
to one another. These are separated by the lamina propria. There is more
lamina propria separating the pits than between the glands.
gastric biopsy degree of pit and glandular separation should be same
throughout the biopsy.
Small area of predominantly mucus
secreting glands surrounding the entrance of the esophagus. Glands are
less coiled than in the antral glands.The pits are shorter than the
Major histological region. Consists of
straight, tubular glands. Strands of muscularis mucosae extend between
the glands from the base. The glands secrete gastric juices as well as
Branched glands open into deep irregular shaped pits. Composed of mucus
secreting cells. Mucus secreted by pyloric glands lubricate and protect
entrance to the duodenum.
Scattered 'G' cells (endocrine cells), secrete gastrin.